
Fifth Door
What they do:
Create and play games with AI
Quick facts:
HQ: San Francisco, CA, United States
This list has 2,716 startups and was last updated on Oct 15, 2026. 785 of them are hiring right now. Biggest hubs: San Francisco (1,471), New York (339), and London (94). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: Scimplify raised $25M (Oct 15, 2026).
Survival statistics →2,620 open roles →

What they do:
Create and play games with AI
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HQ: San Francisco, CA, United States

What they do:
The AI OS for Cities
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HQ: San Francisco, CA, United States

What they do:
Anyone Can Trade
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HQ: San Francisco, CA, United States

What they do:
Making hard molecules for Pharma and Biotech
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HQ: San Francisco, CA, United States

What they do:
product lab. focused on personal ai and context.
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HQ: San Francisco, CA, United States

What they do:
Replacing the restaurant phone line with Voice AI
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HQ: San Francisco, CA, United States

What they do:
Agentic Operating System for Food Supply Chain
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HQ: San Francisco, CA, United States

What they do:
Foundational Voice Models for regional languages
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HQ: San Francisco, CA, United States

What they do:
The future of Social in the age of AI
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HQ: San Francisco, CA, United States

What they do:
Unlocking the world’s most valuable data for frontier AI.
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HQ: London, United Kingdom

What they do:
Agentic AI for Mainframe Operations and Modernization
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HQ: San Francisco, CA, United States

What they do:
AI operating system for home improvement manufacturers
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HQ: New York, NY, United States

What they do:
AI-powered automation for internal audit workflows
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HQ: San Francisco, CA, United States

What they do:
Qualified leads for agentic workflows.
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HQ: San Francisco, CA, United States

What they do:
Helping humans and AI agents understand massive codebases
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HQ: San Francisco, CA, United States

What they do:
The autonomous business platform
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HQ: San Francisco, CA, United States

What they do:
Robots with soul
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HQ: San Francisco, CA, United States

What they do:
AI-powered market due diligence for investment decisions
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HQ: New York, NY, United States

What they do:
AI-Native Med-Legal Firm
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HQ: San Francisco, CA, United States

What they do:
The Forward-Deployed AI Research Engineer
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HQ: San Francisco, CA, United States
What they do:
Custom silicon for power electronics
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HQ: San Francisco, CA, United States

What they do:
Train, eval and build autonomous agents
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What they do:
Multilingual voice agents that outperform humans
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What they do:
Container unloading robots for warehouses
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HQ: Amsterdam, Netherlands

What they do:
Robot Cowboys that Herd Cattle with AI Drones
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What they do:
Robotics
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HQ: San Francisco, CA, United States

What they do:
Agent harnesses for asset managers
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HQ: New York, NY, United States

What they do:
AI Agents for Analog Circuit Design
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HQ: San Francisco, CA, United States

What they do:
AI Native Shopify
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HQ: San Francisco, CA, United States

What they do:
AI recruiters for staffing agencies
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HQ: San Francisco, CA, United States

What they do:
The AI knowledge layer for medical devices
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HQ: Cologne, Germany

What they do:
Building robots to automate wetlabs
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HQ: San Francisco, CA, United States

What they do:
AI-native materials discovery powered by unpublished experimental data
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HQ: San Francisco, CA, United States

What they do:
AI engineer that debugs and fixes production incidents in realtime
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HQ: San Francisco, CA, United States

What they do:
The AI-native firm for public influence.
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HQ: San Francisco, CA, United States

What they do:
AI-Native Medical Group for Mental Health
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HQ: San Francisco, CA, United States