What they do:
We work with governments to implement telemedicine programs.
Quick facts:
HQ: Charleston, SC, United States
Top Startups in South Carolina
This list has 7 startups and was last updated on Oct 15, 2026. Biggest hubs: Charleston (2) and Greenville (2). Largest teams: RingMD, Positional, and Shire Intelligence. Latest round: ChartSpan Medical Technologies raised $50.5M (Jun 29, 2026).
7 startups
What they do:
Shire uses CCTV to run restaurants in real time.
Quick facts:
HQ: Myrtle Beach, SC, United States
Quick facts:
HQ: Greenville, SC, United States
Funding:
$50.5M · Equity · Jun 2026
Quick facts:
HQ: Clemson, SC, United States
Incorporated: 2021
Funding:
$46.4M · SAFE · Jan 2026
Quick facts:
HQ: Okatie, SC, United States
Incorporated: 2023
Funding:
$1.5M · SAFE · Mar 2026
Quick facts:
HQ: Greenville, SC, United States
Funding:
$1.1M · Debt · Feb 2026
Positional
Acquired
What they do:
A modern platform for content marketing & SEO.
Quick facts:
HQ: Charleston, SC, United States
Questions and answers
How many startups are on this list?
There are 7 startups on this list, last updated on Oct 15, 2026.
Which of them are hiring?
None of them shows open roles right now.
Which of them have the largest teams?
By team size: RingMD (32 employees), Positional (5 employees), and Shire Intelligence (4 employees).
Which of them raised money recently?
Latest rounds: ChartSpan Medical Technologies — $50.5M Equity (Jun 2026), Karias Health — $1.5M SAFE (Mar 2026), and Christ Church Episcopal School — $1.1M Debt (Feb 2026).
Where are they based?
The biggest hubs are Charleston (2) and Greenville (2).