What they do:
The autonomous AI model factory
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HQ: San Francisco, CA, United States
Top AI & Data Startups in San Francisco
This list has 1,471 startups and was last updated on Oct 15, 2026. 463 of them are hiring right now. Largest teams: Cruise, Fivetran, and Athelas. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,471 startupsPage 30 of 41
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AI FDE that deploys custom AI agents into ERPs
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HQ: San Francisco, CA, United States
What they do:
Real-world RL environments for robotics models
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HQ: San Francisco, CA, United States
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Simulating Agents Running Industrial Companies
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HQ: San Francisco, CA, United States
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Accurately simulate market response at scale
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HQ: San Francisco, CA, United States
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Self-optimizing neocloud that cuts LLM costs by 100x
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HQ: San Francisco, CA, United States
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AI Agents to Make Local Gov Efficient
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HQ: San Francisco, CA, United States
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Foundation models on enterprise transaction data.
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HQ: San Francisco, CA, United States
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AI-native OS for Real Estate Brokerages
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HQ: San Francisco, CA, United States
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OpenClaw for manufacturers
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HQ: San Francisco, CA, United States
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Defining the frontier of multiplayer AI.
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HQ: San Francisco, CA, United States
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Market for future inference capacity
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HQ: San Francisco, CA, United States
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Training the world's best AI model for quantitative finance.
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HQ: San Francisco, CA, United States
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CrowdStrike for AI Agents
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HQ: San Francisco, CA, United States
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AI Operating System for Wholesale Distribution
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HQ: San Francisco, CA, United States
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Databricks for Enterprise Codebases
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HQ: San Francisco, CA, United States
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Legora for AEC (Architecture, Engineering, & Construction) firms
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HQ: San Francisco, CA, United States
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The world's frontier hacker of AI agents.
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HQ: San Francisco, CA, United States
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Legora for commercial insurance carriers
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HQ: San Francisco, CA, United States
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AI-Native Insurance for Frontier Tech
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HQ: San Francisco, CA, United States
What they do:
Predict how market participants behave
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HQ: San Francisco, CA, United States
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Virtual Reality for Training Robots
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HQ: San Francisco, CA, United States
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AI-Native Engineering Firm designing Data Centers
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HQ: San Francisco, CA, United States
What they do:
Curing cancer. Starting with dogs.
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HQ: San Francisco, CA, United States
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We find where AI agents fail, then train better models to run them.
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HQ: San Francisco, CA, United States
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The AI-native radiology practice
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HQ: San Francisco, CA, United States
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Hotels that run themselves
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HQ: San Francisco, CA, United States
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The AI Operating System for Auto Shops.
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HQ: San Francisco, CA, United States
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Training company-specific models that approve AI actions.
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HQ: San Francisco, CA, United States
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AI Brokers for Industrial Trade
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HQ: San Francisco, CA, United States
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Robots that learn on the job
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HQ: San Francisco, CA, United States
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AI agents for compliance at institutional trading firms
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HQ: San Francisco, CA, United States
What they do:
Multiplayer workspace for agents and humans
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HQ: San Francisco, CA, United States
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Distributed, hardware-agnostic AI inference
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HQ: San Francisco, CA, United States
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Self-optimizing inference cloud for faster, cheaper AI
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HQ: San Francisco, CA, United States
What they do:
Foundational infrastructure for Physical AI
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HQ: San Francisco, CA, United States