Top Cloud Infrastructure Startups in San Francisco

Quick facts:

2 employeesYC W26Early stage

Developer tools Cloud & infrastructure Applied AI & ML

Salus

Hiring

What they do:

Guardrails to validate your agent's actions before they execute

Quick facts:

2 employeesYC W26Early stage

Orthogonal

Hiring

What they do:

Agentic Payments for APIs

Quick facts:

2 employeesYC W26Early stage

Developer tools Cloud & infrastructure Productivity & automation

Reason Machines

Hiring

What they do:

Reason Machines builds Reason Agent, the autonomous software engineer…

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2 employeesYC X26Early stage

Payments Applied AI & ML Cloud & infrastructure

Uno Wallet

Hiring

What they do:

The AI mobile wallet that replaces Apple Pay

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2 employeesYC X26Early stage

Applied AI & ML Cloud & infrastructure

Parasma

Hiring

What they do:

Replacing GPUs with human brain cells

Quick facts:

2 employeesYC S26Early stage

Applied AI & ML Cloud & infrastructure Climate & energy

Edviro

Hiring

What they do:

AI That Operates Energy Infrastructure

Quick facts:

2 employeesYC S26Early stage

Applied AI & ML Developer tools Cloud & infrastructure

Workers IO

Hiring

What they do:

Simulation Environments for Verifying Mission Critical Software

Quick facts:

2 employeesYC F26Early stage

Applied AI & ML Cloud & infrastructure

Guide Labs

What they do:

Frontier models and agents you can learn from, audit, and steer.

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6 employeesYC W24Early stage

Applied AI & ML Developer tools Cloud & infrastructure

Vibrant Labs

What they do:

Autonomously scaling environments

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6 employeesYC W24Early stageRemote

Data & analytics Applied AI & ML Cloud & infrastructure Marketplaces

Sciloop

What they do:

Expert STEM reasoning data for frontier AI labs.

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6 employeesYC F25Early stage

Moda

What they do:

Your agents should never make the same mistake twice.

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6 employeesYC W26Early stage

Limrun

Hiring

What they do:

Extend cloud sandboxes with iOS, Android and more

Quick facts:

1 employeesYC X26Growth stage5 open roles

Cloud & infrastructure Developer tools

InsForge (InstaCloud)

What they do:

The agent-native serverless cloud

Quick facts:

6 employeesYC X26Early stage

Applied AI & ML Developer tools Cloud & infrastructure

Context.dev

What they do:

We give AI agents realtime web context via API

Quick facts:

6 employeesYC S26Early stage

Cloud & infrastructure Applied AI & ML Developer tools

Aden

What they do:

Open source agent generation framework

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5 employeesYC W20Early stage

Cloud & infrastructure Applied AI & ML Developer tools

Freestyle

What they do:

The most powerful sandboxes for AI Agents

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5 employeesYC S24Early stage

Cybersecurity Applied AI & ML Developer tools Cloud & infrastructure

Tinfoil

What they do:

Encrypted AI with verifiable privacy

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5 employeesYC X25Early stage

Applied AI & ML Cloud & infrastructure Robotics & drones

Relling

Hiring

What they do:

deploying the first billion robots for manufacturing

Quick facts:

YC S25Early stage

Developer tools Cloud & infrastructure Data & analytics

s2.dev

What they do:

API for unlimited, durable, real-time streams

Quick facts:

5 employeesYC F25Early stage

AgentPhone

Hiring

What they do:

Phone Numbers for AI Agents

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YC X26Early stage

Cloud & infrastructure Applied AI & ML Developer tools

Riften

What they do:

Earned intelligence for every company

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5 employeesYC S26Early stage

Applied AI & ML Cloud & infrastructure Manufacturing & chips

Operon

Hiring

What they do:

Agentic data layer for manufacturing & process industries.

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YC S26Early stage

Applied AI & ML AI agents & assistants Cloud & infrastructure HR & recruiting

Sona8

What they do:

Context layer for enterprise AI surveying employees with voice agents

Quick facts:

5 employeesYC F26Early stage

Applied AI & ML Cloud & infrastructure Climate & energy

NetworkOcean

What they do:

We build floating solar data centers

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4 employeesYC S24Early stage

Applied AI & ML Cloud & infrastructure

Lilac

What they do:

We sell GPUs.

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4 employeesYC S25Early stageRemote

Cloud & infrastructure Applied AI & ML Developer tools

OneTriangle

What they do:

The cheapest, fastest inference cloud

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4 employeesYC S26Early stage

Cloud & infrastructure Applied AI & ML Data & analytics

Shofo

What they do:

The World's Largest Video Library

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4 employeesYC W26Early stage

Cloud & infrastructure Applied AI & ML Robotics & drones Manufacturing & chips

OpenVector

What they do:

AI that turns any camera to an autonomous worker with real-time vision

Quick facts:

4 employeesYC S26Early stage

Memory Store

What they do:

Company Brain.

Quick facts:

4 employeesYC X26Early stage

Applied AI & ML AI agents & assistants Developer tools Cloud & infrastructure

Speko

What they do:

OpenRouter for Voice AI: one API, every call on the best speech model

Quick facts:

4 employeesYC S26Early stage

Robotics & drones Applied AI & ML Cloud & infrastructure Manufacturing & chips

Dreamscale Labs

What they do:

Real-time cloud inference for robotics.

Quick facts:

4 employeesYC F26Early stage

Tilion

What they do:

Super fast, unblockable browser infra for agents

Quick facts:

4 employeesYC F26Early stage

Developer tools Cloud & infrastructure Sales & marketing

FastJVM

What they do:

Making the JVM faster

Quick facts:

3 employeesYC W17Early stage

Cloud & infrastructure Data & analytics Developer tools

Sunpia

What they do:

Deploy serverless without rewriting code

Quick facts:

3 employeesYC S22Early stageRemote

Cloud & infrastructure Applied AI & ML Data & analytics

Epsilla

What they do:

All-in-one platform to create AI agents with your private knowledge

Quick facts:

3 employeesYC S23Early stageRemote