
Substrate
What they do:
Artificial Intelligence for your medical billing team
Quick facts:
HQ: San Francisco, CA, United States
This list has 1,372 startups and was last updated on Oct 15, 2026. 209 of them are hiring right now. Biggest hubs: San Francisco (419), New York (132), and Boston (50). Largest teams: Redcliffe Lifetech, Gusto, and Truepill. Latest round: Lungpacer Medical raised $7.83M (Oct 14, 2026).
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What they do:
Artificial Intelligence for your medical billing team
Quick facts:
HQ: San Francisco, CA, United States

What they do:
AI scribe for Ambulance Reports
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HQ: New York, NY, United States

What they do:
AI Employees for Healthcare
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HQ: San Francisco, CA, United States

What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States

What they do:
Autonomous medical billing
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HQ: San Francisco, CA, United States

What they do:
We sequence your gut and build the probiotics it’s missing
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HQ: San Francisco, CA, United States

What they do:
Vibecode + deploy HIPAA-compliant internal tools, no eng team needed
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HQ: New York, NY, United States

What they do:
AI-native retrieval engine for medical records
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HQ: Seattle, WA, United States

What they do:
Home care technology for aging parents and their families
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HQ: San Francisco, CA, United States

What they do:
Clinical intelligence layer for skilled nursing facilities.
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What they do:
Catch student behavior problems before they start.
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HQ: San Francisco, CA, United States

What they do:
We are using the gut microbiome to end cancer.
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HQ: San Diego, CA, United States

What they do:
Responsive materials, better lives.
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HQ: Los Angeles, CA, United States

What they do:
We crowdsource food safety reports & detect and prevent outbreaks.
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HQ: Austin, TX, United States

What they do:
Utilizing monogenic disorders to inform and solve highly complex…
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HQ: Portland, OR, United States

What they do:
We built the world's first automated digital pathology lab.
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HQ: Houston, TX, United States

What they do:
XGenomes is building the sequencing technology of the future.
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HQ: Boston, MA, United States

What they do:
Turn manual healthcare process into automated workflows
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HQ: Lehi, UT, United States

What they do:
At-home oral health testing, coaching & care
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HQ: San Francisco, CA, United States

What they do:
Virtual Co-working Community
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HQ: San Francisco, CA, United States

What they do:
The personal coach and companion for cyclists.
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HQ: Truckee, CA, United States

What they do:
AI-designed Affinity Reagents
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HQ: Austin, TX, United States

What they do:
Employee benefit for reproductive and hormone health
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HQ: London, United Kingdom

What they do:
Accidental Death Insurance for Surgery
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What they do:
We stop cows from burping methane.
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HQ: San Francisco, CA, United States

What they do:
Combinations therapy by rational design
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HQ: New York, NY, United States

What they do:
Workflow automation for healthcare providers
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What they do:
Developing long-lasting drug formulations 50% faster
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HQ: Sacramento, CA, United States

What they do:
Scheduling software for digital health clinics to do more with less.
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HQ: San Francisco, CA, United States

What they do:
Creating new protein-based drugs at scale
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What they do:
Search engine for trustworthy medical information.
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HQ: London, United Kingdom

What they do:
Personalized prevention using genetics and AI
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HQ: San Francisco, CA, United States

What they do:
Elevated mRNA for transformative medicines.
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HQ: San Francisco, CA, United States

What they do:
AI workforce management for healthcare
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HQ: San Francisco, CA, United States

What they do:
RNA intelligence for precision medicine
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HQ: San Francisco, CA, United States

What they do:
A research lab for one
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HQ: San Francisco, CA, United States