What they do:
The most capable American-made humanoid robot for $1,688
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HQ: San Francisco, CA, United States
Top Manufacturing Startups in the United States
This list has 404 startups and was last updated on Oct 15, 2026. 92 of them are hiring right now. Biggest hubs: San Francisco (223), New York (26), and Los Angeles (22). Largest teams: Relativity Space, Ginkgo Bioworks, and Gecko Robotics. Latest round: NN raised $53.1M (Oct 14, 2026).
404 startupsPage 5 of 12
What they do:
Metal manufacturing, faster, cheaper, and more versatile.
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HQ: Boston, MA, United States
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
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HQ: San Francisco, CA, United States
YC S26Early stage
Lamb Labs
Hiring
What they do:
Lightning fast chips with hardcoded AI models
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HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Synvivia applies chemical control over cell behavior
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HQ: San Francisco, CA, United States
What they do:
Shiru leverages ML to create proteins to feed the world sustainably.
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HQ: San Francisco, CA, United States
What they do:
We make bacteria and plants that clean up pollution.
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HQ: San Francisco, CA, United States
What they do:
Next-generation biocides for sustainable agriculture at scale
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HQ: New York, NY, United States
What they do:
Enzyme design models.
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HQ: San Francisco, CA, United States
What they do:
Applied research lab for hardware design
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HQ: San Francisco, CA, United States
What they do:
AI that turns any camera to an autonomous worker with real-time vision
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HQ: San Francisco, CA, United States
What they do:
Annotations for robotics data
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HQ: San Francisco, CA, United States
What they do:
Nervous System for Physical AI
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HQ: San Francisco, CA, United States
What they do:
Modernizing Chip Manufacturing Infrastructure
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HQ: Ann Arbor, MI, United States
What they do:
AI-native procurement services for the physical economy
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HQ: San Francisco, CA, United States
What they do:
Robots for high skilled labor powering AI infrastructure
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HQ: San Francisco, CA, United States
What they do:
Real-time cloud inference for robotics.
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HQ: San Francisco, CA, United States
What they do:
Enable robots to operate safely in the real world.
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HQ: San Francisco, CA, United States
What they do:
Skyscrape makes temperature-responsive insulation
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HQ: Portland, OR, United States
What they do:
Using DNA to store data.
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HQ: Boston, MA, United States
What they do:
The Data Platform for Mission‑Critical Systems
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HQ: San Francisco, CA, United States
What they do:
AI chips for ultra-fast training and inference
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HQ: San Francisco, CA, United States
What they do:
Foundation Model for Chemical Manufacturing
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HQ: San Francisco, CA, United States
What they do:
Batteries and solar for $0 upfront to help businesses save money
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HQ: San Francisco, CA, United States
What they do:
An AI-powered test and debug platform for chip developers
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HQ: New York, NY, United States
What they do:
Gigascale Nanomanufacturing
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HQ: San Francisco, CA, United States
What they do:
Datadog for industrial robots
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HQ: San Francisco, CA, United States
What they do:
Robots that repair roads
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HQ: San Francisco, CA, United States
What they do:
We assemble PCBs in under 48 hours for quantities under 10
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HQ: San Francisco, CA, United States
What they do:
Open-source semi-humanoid dev kit → home data → autonomy → 20h/wk
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HQ: Los Angeles, CA, United States
What they do:
AI for the physical world
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HQ: San Francisco, CA, United States
What they do:
AI-native software for managing rail and bulk operations.
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HQ: Olathe, KS, United States
What they do:
Digital transformation for real economy businesses
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HQ: San Francisco, CA, United States
What they do:
Large-scale real-world robot & human data for embodied AI
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HQ: San Francisco, CA, United States
What they do:
Machine intelligence for American Welding
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HQ: Los Angeles, CA, United States
What they do:
Building the Data Infrastructure layer for Physical AI.
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HQ: San Francisco, CA, United States