What they do:
The personal AI agent that keeps up with your work and life.
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HQ: San Francisco, CA, United States
Top AI Assistant Startups
This list has 163 startups and was last updated on Oct 15, 2026. 42 of them are hiring right now. Biggest hubs: San Francisco (81), New York (22), and Los Angeles (6). Largest teams: Leena AI, Magic, and Plivo.
163 startupsPage 4 of 5
What they do:
the AI coding app for thinking.
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HQ: San Francisco, CA, United States
What they do:
Automate bug resolution
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HQ: New York, NY, United States
What they do:
AI agents for insurance claims
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HQ: San Francisco, CA, United States
What they do:
Open source agentic BI for founders
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HQ: San Francisco, CA, United States
What they do:
Your email assistant because you deserve a better morning
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HQ: San Francisco, CA, United States
What they do:
Orca lets you build, discover, and play Minecraft games with friends.
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HQ: San Francisco, CA, United States
What they do:
Build full-stack applications for business operations with AI
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HQ: New York, NY, United States
What they do:
The complete, collaborative workspace for humans and agents
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HQ: Los Angeles, CA, United States
What they do:
AWS for AI Agents
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HQ: San Francisco, CA, United States
What they do:
Founder led hiring for London startups
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What they do:
Simplifying Collaboration for Healthcare Organizations & Professionals
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HQ: New York, NY, United States
What they do:
AI-native operating system for vehicle fleet management
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What they do:
The Cursor for Chip Design - Delivering Silicon-Ready Chip Designs…
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HQ: San Francisco, CA, United States
What they do:
Planet-scale people discovery.
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HQ: San Francisco, CA, United States
What they do:
Lunavo is the AI assistant for carriers.
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HQ: Germany
What they do:
TikTok for Sports Trading
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HQ: San Francisco, CA, United States
What they do:
A proactive desktop copilot. Clippy, but actually good.
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HQ: San Francisco, CA, United States
What they do:
Your personal context, securely portable across every AI app.
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HQ: San Francisco, CA, United States
What they do:
Duolingo for learning anything
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HQ: San Francisco, CA, United States
What they do:
The custom all-in-one OS for each company.
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What they do:
AI agents for high-value professional work
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HQ: London, United Kingdom
What they do:
ChatGPT's memory feature in an open, portable format
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HQ: San Francisco, CA, United States
What they do:
AI automated prior-auths for private medical practices
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HQ: Seattle, WA, United States
What they do:
AI agent that manages manufacturing operations over text
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HQ: San Francisco, CA, United States
What they do:
Camera-free AI glasses. Your AI, out in the world.
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HQ: San Francisco, CA, United States
What they do:
building the open agent runtime
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HQ: Ankara, Turkey
What they do:
Visual AI shopping
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HQ: New York, NY, United States
YC S21Early stage
What they do:
AI Operations Partner for Mortgage & Banking
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HQ: New York, NY, United States
YC W22Early stage
What they do:
Random labs is building long running autonomous coding agents.
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HQ: San Francisco, CA, United States
YC S24Early stage
DeepSource
Acquired
What they do:
Unified DevSecOps platform, helping developers ship good code.
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HQ: San Francisco, CA, United States
Symplex
Acquired
What they do:
Applied Reinforcement Learning Research Laboratory
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HQ: New York, NY, United States
Deasy Labs
Acquired
What they do:
Metadata for GenAI workflows
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HQ: New York, NY, United States
Benchmark
Acquired
What they do:
Decision infrastructure for investment firms
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HQ: New York, NY, United States
Brewit
Acquired
What they do:
Conversational data analytics for every team
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HQ: San Francisco, CA, United States
Bytebot
Acquired
What they do:
Bytebot is the open source container for AI desktop agents.
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HQ: Boston, MA, United States