What they do:
iPhone-based driver monitoring for commercial fleets.
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HQ: San Francisco, CA, United States
Top Hard Tech Startups
This list has 143 startups and was last updated on Oct 15, 2026. 42 of them are hiring right now. Biggest hubs: San Francisco (70), Los Angeles (9), and Boston (8). Largest teams: Helion Energy, SRTX, and SiPhox Health. Latest round: CircuitHub raised $25.5M (May 13, 2026).
143 startupsPage 3 of 4
What they do:
Autonomous street sweeping as a service by retro-fitting vehicles
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HQ: San Francisco, CA, United States
What they do:
A platform to make artificial viruses as cancer therapeutics.
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HQ: New York, NY, United States
What they do:
Unified flight software and hardware for the mission of tomorrow
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HQ: San Francisco, CA, United States
Spaceium Inc
Hiring
What they do:
In-Space Refueling
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What they do:
Building lunar landers
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HQ: London, United Kingdom
What they do:
A new kind of camera that can see through walls.
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HQ: San Francisco, CA, United States
What they do:
The most capable American-made humanoid robot for $1,688
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HQ: San Francisco, CA, United States
What they do:
Metal manufacturing, faster, cheaper, and more versatile.
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HQ: Boston, MA, United States
What they do:
Emission free hydrogen electric aircraft
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What they do:
Building a nervous system for the atmosphere
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HQ: San Francisco, CA, United States
What they do:
We build floating solar data centers
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HQ: San Francisco, CA, United States
What they do:
We're building robot birds for surveillance.
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HQ: Los Angeles, CA, United States
What they do:
We turn waste gases into supply-secure chemicals
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HQ: Chicago, IL, United States
What they do:
Modernizing Chip Manufacturing Infrastructure
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HQ: Ann Arbor, MI, United States
What they do:
The neural engine for autonomous robots
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HQ: St. Louis, MO, United States
What they do:
Helping physicians select the right therapy for breast cancer patients
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HQ: Austin, TX, United States
What they do:
The Data Platform for Mission‑Critical Systems
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HQ: San Francisco, CA, United States
What they do:
AI chips for ultra-fast training and inference
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HQ: San Francisco, CA, United States
What they do:
Gigascale Nanomanufacturing
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HQ: San Francisco, CA, United States
What they do:
Engineering microbes for miners to unlock billions in trapped metal
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HQ: San Francisco, CA, United States
What they do:
Frontier grows scalable biological brains as an ML training substrate
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HQ: London, United Kingdom
What they do:
USA-made magnetics for robotics and defense.
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HQ: Boston, MA, United States
What they do:
AI-native test infrastructure layer for hardware companies
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HQ: San Francisco, CA, United States
What they do:
Turns real businesses into robotics data vendors
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HQ: San Francisco, CA, United States
What they do:
Evals for robots
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HQ: San Francisco, CA, United States
What they do:
100% automated inspection for consumer electronics parts
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HQ: San Francisco, CA, United States
What they do:
The highest-accuracy global weather data from low-cost flat satellites
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HQ: Orem, UT, United States
What they do:
The Operating System for Maritime
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HQ: Singapore
What they do:
Neurostimulation implant to restore hearing & speech understanding
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HQ: San Francisco, CA, United States
What they do:
Automating nutrition tracking.
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HQ: San Francisco, CA, United States
What they do:
Converting biology into digital molecular maps
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HQ: Philadelphia, PA, United States
What they do:
Robotic Training Data at Scale
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HQ: Boston, MA, United States
What they do:
Distributed energy infrastructure unlocking grid power to data centers
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HQ: London, United Kingdom
What they do:
Robots for the inspection and maintenance of data centers
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HQ: Boston, MA, United States
What they do:
Building intellectually curious AI
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HQ: San Francisco, CA, United States