What they do:
Energy Superintelligence, AI that operates critical infrastructure
Quick facts:
Top Infrastructure Startups
This list has 417 startups and was last updated on Oct 15, 2026. 111 of them are hiring right now. Biggest hubs: San Francisco (271), New York (38), and London (10). Largest teams: Fivetran, Firebase, and Heroku. Latest round: Supabase raised $150M (Oct 2, 2026).
417 startupsPage 5 of 12
What they do:
Recover from any outage in 10 minutes or less.
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HQ: Durham, NC, United States
What they do:
Automated WireGuard networks for distributed systems and Kubernetes
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HQ: Austin, TX, United States
What they do:
The orchestration platform for teams who ship.
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HQ: New York, NY, United States
Zettascale Computing
Hiring
What they do:
Chips for frontier AI
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HQ: San Francisco, CA, United States
What they do:
The Localization Engineering Platform
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HQ: San Francisco, CA, United States
Unsiloed AI
Hiring
What they do:
API for parsing multimodal unstructured data
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HQ: San Francisco, CA, United States
Lemma
Hiring
What they do:
Production Monitoring for AI agents
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HQ: San Francisco, CA, United States
Cumulus Labs
Hiring
What they do:
The Fastest Multimodal Inference OS
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HQ: San Francisco, CA, United States
Salus
Hiring
What they do:
Guardrails to validate your agent's actions before they execute
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HQ: San Francisco, CA, United States
Orthogonal
Hiring
What they do:
Agentic Payments for APIs
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HQ: San Francisco, CA, United States
Uno Wallet
Hiring
What they do:
The AI mobile wallet that replaces Apple Pay
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HQ: San Francisco, CA, United States
Parasma
Hiring
What they do:
Replacing GPUs with human brain cells
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HQ: San Francisco, CA, United States
Edviro
Hiring
What they do:
AI That Operates Energy Infrastructure
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HQ: San Francisco, CA, United States
Workers IO
Hiring
What they do:
Simulation Environments for Verifying Mission Critical Software
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HQ: San Francisco, CA, United States
What they do:
Frontier models and agents you can learn from, audit, and steer.
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HQ: San Francisco, CA, United States
What they do:
Autonomously scaling environments
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HQ: San Francisco, CA, United States
What they do:
The fastest & most scalable graph-vector database on the market
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HQ: London, United Kingdom
What they do:
Expert STEM reasoning data for frontier AI labs.
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HQ: San Francisco, CA, United States
What they do:
Your agents should never make the same mistake twice.
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HQ: San Francisco, CA, United States
Limrun
Hiring
What they do:
Extend cloud sandboxes with iOS, Android and more
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HQ: San Francisco, CA, United States
What they do:
The agent-native serverless cloud
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HQ: San Francisco, CA, United States
What they do:
We give AI agents realtime web context via API
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HQ: San Francisco, CA, United States
What they do:
Open source agent generation framework
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HQ: San Francisco, CA, United States
QuestDB
Hiring
What they do:
Data platform for mission-critical real-time workloads
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HQ: London, United Kingdom
YC S20Early stage
What they do:
Building the next generation of visual media
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HQ: New York, NY, United States
What they do:
The complete production quality platform. AI-powered E2E testing,…
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HQ: Limerick, Ireland
What they do:
Bare-metal access to Brazil's Open Finance and Pix systems
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What they do:
Account abstraction wallets as a service
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HQ: Los Angeles, CA, United States
What they do:
Unified Hardware Control and Data Processing Software
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HQ: Denver, CO, United States
What they do:
The most powerful sandboxes for AI Agents
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HQ: San Francisco, CA, United States
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
API for unlimited, durable, real-time streams
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HQ: San Francisco, CA, United States
AgentPhone
Hiring
What they do:
Phone Numbers for AI Agents
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Earned intelligence for every company
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HQ: San Francisco, CA, United States
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage