What they do:
Enteprise AI
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HQ: San Francisco, CA, United States
Top AI & Data Startups in California
This list has 1,550 startups and was last updated on Oct 15, 2026. 481 of them are hiring right now. Biggest hubs: San Francisco (1,471), Los Angeles (51), and San Diego (5). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,550 startupsPage 19 of 44
What they do:
The proactive agent that achieves growth goals for businesses, fully…
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HQ: San Francisco, CA, United States
What they do:
Your biopharma team, from molecule design to portfolio strategy
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HQ: San Francisco, CA, United States
Knowtex
Hiring
What they do:
Making doctors 2x more efficient with AI note-taking & charge capture
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HQ: San Francisco, CA, United States
Automat
Hiring
What they do:
Agentic automation that understands context, recovers, and improves.
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HQ: San Francisco, CA, United States
YC W23Growth stage
What they do:
AI-Native Process Mining and Enterprise Transformation Platform
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HQ: San Francisco, CA, United States
What they do:
AI for ASIC Design Verification
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HQ: San Francisco, CA, United States
PromptArmor
Hiring
What they do:
LLM Security and Compliance
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HQ: San Francisco, CA, United States
YC W24Early stage
What they do:
Helps teams work effectively with AI coding agents.
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HQ: San Francisco, CA, United States
What they do:
CPQ for humans and agents
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HQ: Santa Barbara, CA, United States
What they do:
Generate fast, reliable APIs for any platform
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HQ: San Francisco, CA, United States
What they do:
Ultimate AI Math Problem Solver to Revolutionize Personalized Learning
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HQ: San Francisco, CA, United States
What they do:
Tools for agent verification
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HQ: San Francisco, CA, United States
What they do:
Starbucks app for restaurants
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HQ: San Francisco, CA, United States
What they do:
Gen AI molecular simulations that reproduce wetlab results
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HQ: San Francisco, CA, United States
What they do:
Faster, more profitable background checks with AI
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HQ: Los Angeles, CA, United States
What they do:
Stormy runs the office so your crew can run the work.
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HQ: San Francisco, CA, United States
What they do:
AI agents that handles complex billing and revenue
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HQ: San Francisco, CA, United States
What they do:
At-cost preventive health: Labs, Scans, Genetics, Supplements and Rx
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HQ: San Francisco, CA, United States
Emergent
Hiring
What they do:
AI app builder that turns your ideas into monetizable software.
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HQ: San Francisco, CA, United States
YC S24Growth stage
What they do:
Helping hospitals identify and prevent avoidable harm using AI
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HQ: San Francisco, CA, United States
What they do:
The most powerful sandboxes for AI Agents
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HQ: San Francisco, CA, United States
What they do:
AI app builder for creating and launching iPhone apps
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HQ: San Francisco, CA, United States
What they do:
Voice AI teams for medicare agencies.
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HQ: San Francisco, CA, United States
What they do:
Frontier Data
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HQ: San Francisco, CA, United States
Wildcard
Hiring
What they do:
AEO/GEO for E-Commerce and Retail
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HQ: San Francisco, CA, United States
YC W25Early stage
What they do:
AI-powered robotics for scientific lab automation.
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HQ: San Francisco, CA, United States
What they do:
Encrypted AI with verifiable privacy
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HQ: San Francisco, CA, United States
What they do:
Turn scattered data into one platform for decision-making
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HQ: San Francisco, CA, United States
What they do:
AI agents for risk-bearing healthcare organizations
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HQ: San Francisco, CA, United States
Adaptional
Hiring
What they do:
AI-powered insurance claims review
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI advisor for retail investors
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HQ: San Francisco, CA, United States
What they do:
The E2E testing layer for AI-driven development
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HQ: San Francisco, CA, United States
Proliferate
Hiring
What they do:
Do your life's work with agents
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HQ: San Francisco, CA, United States
YC S25Early stage
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI agents for E2E testing across mobile & web
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HQ: San Francisco, CA, United States