What they do:
Unlocking the power of biotech with modern software for modern science
Quick facts:
HQ: San Francisco, CA, United States
Top Biotech Startups in California
This list has 199 startups and was last updated on Oct 15, 2026. 21 of them are hiring right now. Biggest hubs: San Francisco (134), San Diego (14), and Irvine (5). Largest teams: Benchling, BillionToOne, and Ansa Biotechnologies. Latest round: Renue Life Sciences raised $250K (Oct 14, 2026).
199 startupsPage 1 of 6
Notable Labs
HiringPublic
What they do:
Personalized drug discovery for blood cancer.
Quick facts:
HQ: San Francisco, CA, United States
Pardes Biosciences
Public
What they do:
We break viruses
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HQ: San Francisco, CA, United States
BillionToOne
HiringPublic
What they do:
The genetic testing platform detecting and measuring disease.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Artificial intelligence for drug discovery.
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HQ: San Francisco, CA, United States
Funding:
$19.8M · Equity · Mar 2026
What they do:
Altay develops disease-modifying therapies targeting transcription…
Quick facts:
HQ: San Francisco, CA, United States
Funding:
$15.7M · Equity · Oct 2026
What they do:
AI drug discovery platform for neurotherapeutics
Quick facts:
HQ: San Francisco, CA, United States
Funding:
$2.16M · Options · Feb 2026
What they do:
Next-generation DNA synthesis using enzymes
Quick facts:
HQ: San Francisco, CA, United States
Verge Genomics
Hiring
What they do:
We use human data and AI to develop better drugs faster.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Lygos (W16) built and commercialized sustainable, high-performance…
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HQ: San Francisco, CA, United States
Living Carbon
Hiring
What they do:
maximizing biomass on low quality land
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HQ: San Francisco, CA, United States
What they do:
We grow cells for biotech companies.
Quick facts:
HQ: San Francisco, CA, United States
Synthio Labs
Hiring
What they do:
Agentic AI platform for Pharma GTM teams
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Empowering women. Period.
Quick facts:
HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Targeting Cancer with Click Chemistry
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HQ: San Francisco, CA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
Quick facts:
HQ: San Francisco, CA, United States
Tamarind Bio
Hiring
What they do:
AI Inference Platform for Drug Discovery
Quick facts:
HQ: San Francisco, CA, United States
Numen
Hiring
What they do:
Engineering a future without cancer deaths.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
ZBiotics makes genetically engineered probiotics.
Quick facts:
HQ: San Francisco, CA, United States
Probably Genetic
Hiring
What they do:
Patient Intelligence Platform for Genetic Disease
Quick facts:
HQ: San Francisco, CA, United States
General Proximity
Hiring
What they do:
The next generation of induced-proximity medicines.
Quick facts:
HQ: San Francisco, CA, United States
Anthrogen
Hiring
What they do:
We work on generalizable tools for the next era of biotech.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Fermentation-derived natural products to solve health problems
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HQ: San Diego, CA, United States
What they do:
Using CRISPR to find treatments for cancer and inflammation
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HQ: San Francisco, CA, United States
What they do:
DNA App Store
Quick facts:
HQ: San Francisco, CA, United States
Diffuse Bio
Hiring
What they do:
Generative AI for protein design
Quick facts:
HQ: San Francisco, CA, United States
What they do:
FidoCure® is the leader in Precision Medicine for Canine Oncology.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
We create activating antibodies to treat diseases others can’t.
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HQ: San Francisco, CA, United States
SafeBeat
Hiring
What they do:
First ECG AI to go beyond diagnostics and recommend treatment
Quick facts:
HQ: San Francisco, CA, United States
Epinoma
Hiring
What they do:
We engineer proteins that control the operating system of biology.
Quick facts:
HQ: San Francisco, CA, United States
Origin
Hiring
What they do:
AI and Data for Cancer Therapeutics
Quick facts:
HQ: San Francisco, CA, United States
What they do:
We design and build microbes to make chemicals greener at lower cost.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The free HIV vaccine.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Finding the right cancer drug for each patient.
Quick facts:
HQ: Walnut, CA, United States
Questions and answers
How many startups are on this list?
There are 199 startups on this list, last updated on Oct 15, 2026.
Which of them are hiring?
21 of them are hiring right now, including Notable Labs, BillionToOne, and Verge Genomics.
Which of them have the largest teams?
By team size: Benchling (750 employees), BillionToOne (300 employees), and Ansa Biotechnologies (72 employees).
Which of them raised money recently?
Latest rounds: Renue Life Sciences — $250K (Oct 2026), Tempest Therapeutics — $7.5M Options (Oct 2026), and Lionheart Health — $388K Equity (Oct 2026).
Where are they based?
The biggest hubs are San Francisco (134), San Diego (14), and Irvine (5).