What they do:
AI-powered content creation infrastructure for apps
Quick facts:
HQ: San Francisco, CA, United States
Top AI & Data Startups in San Francisco
This list has 1,471 startups and was last updated on Oct 15, 2026. 463 of them are hiring right now. Largest teams: Cruise, Fivetran, and Athelas. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,471 startupsPage 4 of 41
What they do:
Open-source, serverless vectordb for production-scale generative AI
Quick facts:
HQ: San Francisco, CA, United States
Truewind
Hiring
What they do:
AI-Powered Accounting
Quick facts:
HQ: San Francisco, CA, United States
Hyperbound
Hiring
What they do:
Revenue Activation Platform
Quick facts:
HQ: San Francisco, CA, United States
Outset
Hiring
What they do:
AI-powered user interviews
Quick facts:
HQ: San Francisco, CA, United States
Giga
Hiring
What they do:
AI Support Agent for Enterprises.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI code review agent with complete context of your codebase
Quick facts:
HQ: San Francisco, CA, United States
Reducto
Hiring
What they do:
The complete agentic document platform
Quick facts:
HQ: San Francisco, CA, United States
Alex
Hiring
What they do:
Alex is the AI recruiter for hiring great people.
Quick facts:
HQ: San Francisco, CA, United States
AfterQuery
Hiring
What they do:
Applied research lab curating data solutions for foundation model…
Quick facts:
HQ: San Francisco, CA, United States
Metriport
Hiring
What they do:
Healthcare data infrastructure for next generation care delivery.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI that finds the right buyers and books sales meetings
Quick facts:
HQ: San Francisco, CA, United States
Synthio Labs
Hiring
What they do:
Agentic AI platform for Pharma GTM teams
Quick facts:
HQ: San Francisco, CA, United States
Two Dots
Hiring
What they do:
AI fraud prevention and underwriting agent
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Real-World Data for Health Innovation
Quick facts:
HQ: San Francisco, CA, United States
Uplane
Hiring
What they do:
Replace marketing agencies with AI
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Empowering women. Period.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
A new kind of power for finance teams
Quick facts:
HQ: San Francisco, CA, United States
Atomic
Hiring
What they do:
API that lets companies embed investment accounts into their services
Quick facts:
HQ: San Francisco, CA, United States
Mach9
Hiring
What they do:
AI CAD Software for Civil Engineering
Quick facts:
HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
Quick facts:
HQ: San Francisco, CA, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
Quick facts:
HQ: San Francisco, CA, United States
mdhub
Hiring
What they do:
AI-native operating system for behavioral health clinics.
Quick facts:
HQ: San Francisco, CA, United States
Ember
Hiring
What they do:
AI RCM. Increase net revenue by 16%.
Quick facts:
HQ: San Francisco, CA, United States
Harper
Hiring
What they do:
AI-native commercial insurance brokerage
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The Javascript framework for building AI agents, from the Gatsby devs
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Handl converts documents (invoices, income stabs, custom forms, etc.)…
Quick facts:
HQ: San Francisco, CA, United States
HUD
Hiring
What they do:
Platform and marketplace for RL environments and AI data
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Replika is an AI friend that you can talk to designed to make you…
Quick facts:
HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
Quick facts:
HQ: San Francisco, CA, United States
Respan
Hiring
What they do:
Self-driving observability, evals, and gateway for AI agents
Quick facts:
HQ: San Francisco, CA, United States
Datrics
Hiring
What they do:
Generative AI Healthcare Coding Automation
Quick facts:
HQ: San Francisco, CA, United States
Entangl
Hiring
What they do:
Find & resolve issues in data center engineering & operations using AI
Quick facts:
HQ: San Francisco, CA, United States
IOMETE
Hiring
What they do:
Self-hosted data lakehouse platform
Quick facts:
HQ: San Francisco, CA, United States
Strada
Hiring
What they do:
AI agents that run insurance operations
Quick facts:
HQ: San Francisco, CA, United States