Layerup
Hiring
What they do:
Agentic AI OS for Financial Services and Insurance
Quick facts:
HQ: San Francisco, CA, United States
Top AI & Data Startups in San Francisco
This list has 1,471 startups and was last updated on Oct 15, 2026. 463 of them are hiring right now. Largest teams: Cruise, Fivetran, and Athelas. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,471 startupsPage 7 of 41
1stCollab
Hiring
What they do:
Performance-Optimized Influencer Marketing at Scale
Quick facts:
HQ: San Francisco, CA, United States
Skyvern
Hiring
What they do:
Open Source AI Agent to automate browser workflows via an API
Quick facts:
HQ: San Francisco, CA, United States
ParadeDB
Hiring
What they do:
You should just use Postgres.
Quick facts:
HQ: San Francisco, CA, United States
Simple AI
Hiring
What they do:
AI voice that sells
Quick facts:
HQ: San Francisco, CA, United States
Lanesurf
Hiring
What they do:
Book any load in 10 minutes
Quick facts:
HQ: San Francisco, CA, United States
Trelium
Hiring
What they do:
AI Agents for Enterprise Wide Operations
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Olark gives you an AI agent that works your marketing funnel 24/7
Quick facts:
HQ: San Francisco, CA, United States
Flockjay
Hiring
What they do:
AI-driven learning, content, and coaching for sales teams
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Ramen VR is transforming game development with advanced XR + AI tools.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Using CRISPR to find treatments for cancer and inflammation
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HQ: San Francisco, CA, United States
What they do:
Affogato AI — Your Agent for instant TikToks, Reels, and ads.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI SDET for mobile apps
Quick facts:
HQ: San Francisco, CA, United States
Dart
Hiring
What they do:
The work and agent management platform
Quick facts:
HQ: San Francisco, CA, United States
Julius
Hiring
What they do:
Build and analyze things with AI
Quick facts:
HQ: San Francisco, CA, United States
Coris
Hiring
What they do:
AI risk and ops platform for Payment Processors, Banks, SaaS…
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HQ: San Francisco, CA, United States
Rubbrband
Hiring
What they do:
A new kind of creative company.
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HQ: San Francisco, CA, United States
Reflex
Hiring
What they do:
The operating system for building mission-critical enterprise apps.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Social listening for the video era
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HQ: San Francisco, CA, United States
Magic Patterns
Hiring
What they do:
Go from idea to production with AI.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Automating Healthcare Revenue Cycle Management with AI Workforce
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HQ: San Francisco, CA, United States
Diffuse Bio
Hiring
What they do:
Generative AI for protein design
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI Agents For RFP and Questionnaire Response Automation
Quick facts:
HQ: San Francisco, CA, United States
Event Horizon Labs
Hiring
What they do:
AI research lab automating all of investing
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HQ: San Francisco, CA, United States
Zep AI
Hiring
What they do:
The unified context layer for enterprise data
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HQ: San Francisco, CA, United States
TrueClaim
Hiring
What they do:
Transparent, AI-powered healthcare TPA.
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HQ: San Francisco, CA, United States
Coval
Hiring
What they do:
Simulation & Evaluation that scales voice and chat AI agents
Quick facts:
HQ: San Francisco, CA, United States
Mem0
Hiring
What they do:
The Memory layer for AI Agents
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HQ: San Francisco, CA, United States
Hamming AI
Hiring
What they do:
Complete QA platform for voice agents
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HQ: San Francisco, CA, United States
David AI
Hiring
What they do:
Data for audio AI
Quick facts:
HQ: San Francisco, CA, United States
Thunder Compute
Hiring
What they do:
GPUs for Agents
Quick facts:
HQ: San Francisco, CA, United States
Syntra
Hiring
What they do:
Faster healthcare payments
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HQ: San Francisco, CA, United States
CTGT
Hiring
What they do:
The deterministic layer for frontier intelligence
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HQ: San Francisco, CA, United States
Proception Inc
Hiring
What they do:
Making humanoids dexterous enough to thread a needle
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HQ: San Francisco, CA, United States
Sim
Hiring
What they do:
Build autonomous AI agents for enterprise systems
Quick facts:
HQ: San Francisco, CA, United States
Bluejay
Hiring
What they do:
Test, monitor, and improve your voice and chat AI agents
Quick facts:
HQ: San Francisco, CA, United States