What they do:
AI-native back-office for banks and fintechs
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
Top AI & Data Startups in the United States
This list has 2,142 startups and was last updated on Oct 16, 2026. 661 of them are hiring right now. Biggest hubs: San Francisco (1,477), New York (340), and Los Angeles (51). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: OpsMate AI raised $3.38M (Oct 15, 2026).
2,142 startupsPage 47 of 60
What they do:
AI-controlled optical switching for AI clusters
Quick facts:
HQ: Boston, MA, United States
YC S26Early stage
What they do:
AI Employee for Manufacturing Operations
Quick facts:
HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Engineering Intelligence and Token Optimization for the AI-Coding Era
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
The simplest interface in the world to talk AI models + spawn agents
Quick facts:
HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Teaching AI to Design Chips
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
World Model for Freight
Quick facts:
HQ: New York, NY, United States
YC S26Early stage
What they do:
cards for AI agents
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Autopilot for Flight Operations
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
AI teammates for your business-critical work.
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
AI-native Accounting Firm that's killing Deloitte
Quick facts:
HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Persistent sandboxes for agents like hermes, openclaw, claude code
Quick facts:
HQ: New York, NY, United States
YC F26Early stage
What they do:
Resin helps engineers design electronics faster and more reliably
Quick facts:
HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
AI-guided ballistic missiles, cheap enough to field in numbers that…
Quick facts:
HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
A graph based IDE for when agents program faster than you can read
Quick facts:
HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
Mashup any game
Quick facts:
HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
Commercial insurance for small businesses
Quick facts:
HQ: Salt Lake City, UT, United States
YC F26Early stage
What they do:
The crowdsourced benchmark for AI-generated music and music production
Quick facts:
HQ: San Francisco, CA, United States
Cruise
Acquired
What they do:
Self-driving cars.
Quick facts:
HQ: San Francisco, CA, United States
Segment
Acquired
What they do:
Software and APIs to collect, clean, and control customer data.
Quick facts:
HQ: San Francisco, CA, United States
Heap
Acquired
What they do:
Captures user interactions with no code to generate analytics.
Quick facts:
HQ: Seattle, WA, United States
Quick facts:
HQ: San Diego, CA, United States
Funding:
$592M · Equity · May 2026
Quick facts:
HQ: San Francisco, CA, United States
Incorporated: 2023
Funding:
$435M · Equity · Jan 2026
Quick facts:
HQ: San Francisco, CA, United States
Incorporated: 2024
Funding:
$364M · Equity · Jun 2026
Quick facts:
HQ: Reno, NV, United States
Incorporated: 2023
Funding:
$234M · Equity · May 2026
Quick facts:
HQ: San Francisco, CA, United States
Incorporated: 2022
Funding:
$200M · Equity · Apr 2026
Quick facts:
HQ: San Francisco, CA, United States
Incorporated: 2023
Funding:
$150M · Equity · Feb 2026
Quick facts:
HQ: Arlington, VA, United States
Incorporated: 2024
Funding:
$123M · Equity · Sep 2026
Quick facts:
HQ: New York, NY, United States
Incorporated: 2022
Funding:
$120M · Equity · Jun 2026
Quick facts:
HQ: Seattle, WA, United States
Incorporated: 2022
Funding:
$80M · Equity · Feb 2026
Quick facts:
HQ: New York, NY, United States
Funding:
$73.1M · Equity · May 2026
Quick facts:
HQ: Seattle, WA, United States
Incorporated: 2023
Funding:
$65M · Equity · Jun 2026
Quick facts:
HQ: Goleta, CA, United States
Incorporated: 2024
Funding:
$50M · Equity · May 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$40M · Equity · Feb 2026
Quick facts:
HQ: Brooklyn, NY, United States
Incorporated: 2025
Funding:
$39.6M · Equity · May 2026
Quick facts:
HQ: New York City, NY, United States
Incorporated: 2025
Funding:
$33.7M · Equity · May 2026