Resquared
Hiring
What they do:
Marketing automation platform for selling to local businesses.
Quick facts:
HQ: Philadelphia, PA, United States
Top B2B Software Startups in Pennsylvania
This list has 31 startups and was last updated on Oct 15, 2026. 3 of them are hiring right now. Biggest hubs: Philadelphia (11) and Pittsburgh (10). Largest teams: Resquared, Nextmv, and FIRST. Latest round: Aarogya Tech raised $1.93M (Jun 1, 2026).
31 startups
FIRST
Hiring
What they do:
The best way for any business to offer delivery.
Quick facts:
HQ: Philadelphia, PA, United States
What they do:
Network monitoring from the end-user perspective
Quick facts:
HQ: Pittsburgh, PA, United States
Orchid
Hiring
What they do:
AI-powered EHR for independent mental health professionals
Quick facts:
HQ: Philadelphia, PA, United States
What they do:
The SAFE for commercial contracts
Quick facts:
HQ: Philadelphia, PA, United States
What they do:
Enterprise Voice Agents
Quick facts:
HQ: Pittsburgh, PA, United States
What they do:
Converting biology into digital molecular maps
Quick facts:
HQ: Philadelphia, PA, United States
What they do:
Create, edit, and share procedural material graphs.
Quick facts:
HQ: Pittsburgh, PA, United States
Quick facts:
HQ: Philadelphia, PA, United States
Funding:
$197M · Equity · Jan 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$40M · Equity · Feb 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Incorporated: 2022
Funding:
$10.2M · Equity · Jan 2026
Quick facts:
HQ: Philadelphia, PA, United States
Incorporated: 2023
Funding:
$8.67M · Equity · Jan 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Incorporated: 2021
Funding:
$8.6M · Equity · Jan 2026
Quick facts:
HQ: Penn Valley, PA, United States
Incorporated: 2022
Funding:
$7.87M · Equity · Apr 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$4.89M · Debt · Mar 2026
Quick facts:
HQ: Philadelphia, PA, United States
Funding:
$3.32M · Equity + debt · Apr 2026
Quick facts:
HQ: Blue Bell, PA, United States
Funding:
$3M · Equity · Feb 2026
Quick facts:
HQ: Pittsburg, PA, United States
Incorporated: 2024
Funding:
$2.94M · Equity · Mar 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$2.25M · Equity · May 2026
Quick facts:
HQ: Hughesville, PA, United States
Funding:
$2.15M · Mar 2026
Quick facts:
HQ: Reading, PA, United States
Incorporated: 2022
Funding:
$1.93M · Equity · Jun 2026
Quick facts:
HQ: Haverford, PA, United States
Incorporated: 2021
Funding:
$1.69M · Equity · May 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$1.46M · Equity · Mar 2026
Quick facts:
HQ: Wayne, PA, United States
Incorporated: 2025
Funding:
$1.15M · Debt · Apr 2026
Quick facts:
HQ: Tyrone, PA, United States
Funding:
$1.1M · Debt · Jun 2026
Quick facts:
HQ: Middletown, PA, United States
Incorporated: 2025
Funding:
$1.07M · SAFE · Mar 2026
Nextmv
Acquired
What they do:
A DecisionOps platform that accelerates optimization AI teams
Quick facts:
HQ: Philadelphia, PA, United States
Reflect
Acquired
What they do:
No-code test automation for web apps
Quick facts:
HQ: Villanova, PA, United States
Outerbase
Acquired
What they do:
The interface for your database
Quick facts:
HQ: Pittsburgh, PA, United States
Chatter
Acquired
What they do:
Dead simple LLM testing and iteration
Quick facts:
HQ: Philadelphia, PA, United States
Buzzle
Shut down
What they do:
Automatic voice-of-customer trends & metrics from sales conversations.
Quick facts:
HQ: Philadelphia, PA, United States
Questions and answers
How many startups are on this list?
There are 31 startups on this list, last updated on Oct 15, 2026.
Which of them are hiring?
3 of them are hiring right now, including Resquared, FIRST, and Orchid.
Which of them have the largest teams?
By team size: Resquared (40 employees), Nextmv (22 employees), and FIRST (12 employees).
Which of them raised money recently?
Latest rounds: Aarogya Tech — $1.93M Equity (Jun 2026), InspectionGo — $1.1M Debt (Jun 2026), and Thoroughcare — $2.25M Equity (May 2026).
Where are they based?
The biggest hubs are Philadelphia (11) and Pittsburgh (10).