What they do:
Regulating the immune system to block cancer & autoimmune diseases
Quick facts:
HQ: Philadelphia, PA, United States
Top Biotech Startups in Pennsylvania
This list has 16 startups and was last updated on Oct 15, 2026. Biggest hubs: Philadelphia (8) and Pittsburgh (2). Latest round: Myris Therapeutics raised $500K (Oct 14, 2026).
16 startups
What they do:
Converting biology into digital molecular maps
Quick facts:
HQ: Philadelphia, PA, United States
Quick facts:
HQ: Philadelphia, PA, United States
Incorporated: 2023
Funding:
$56.9M · Equity · Jan 2026
Quick facts:
HQ: Philadelphia, PA, United States
Funding:
$28M · Equity · May 2026
Quick facts:
HQ: Philadelphia, PA, United States
Incorporated: 2023
Funding:
$15.1M · Equity · Jun 2026
Quick facts:
HQ: Penn Valley, PA, United States
Incorporated: 2022
Funding:
$7.87M · Equity · Apr 2026
Quick facts:
HQ: Bethlehem, PA, United States
Funding:
$4.83M · Equity · Mar 2026
Quick facts:
HQ: Philadelphia, PA, United States
Incorporated: 2025
Funding:
$4M · Options · Jun 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Funding:
$3.26M · Equity · Mar 2026
Quick facts:
HQ: Exton, PA, United States
Incorporated: 2022
Funding:
$3M · Equity · Feb 2026
Quick facts:
HQ: Philadelpia, PA, United States
Incorporated: 2023
Funding:
$3M · Equity · Jan 2026
Quick facts:
HQ: Philadelphia, PA, United States
Incorporated: 2025
Funding:
$2.52M · Equity · May 2026
Quick facts:
HQ: Pittsburgh, PA, United States
Incorporated: 2025
Funding:
$1.64M · SAFE · Apr 2026
Quick facts:
HQ: Chesterbrook, PA, United States
Incorporated: 2025
Funding:
$1.57M · Equity · Mar 2026
Quick facts:
HQ: Sharpsburg, PA, United States
Incorporated: 2022
Funding:
$500K · Debt · Oct 2026
Quick facts:
HQ: Philadelphia, PA, United States
Funding:
$185K · Debt · Oct 2026
Questions and answers
How many startups are on this list?
There are 16 startups on this list, last updated on Oct 15, 2026.
Which of them are hiring?
None of them shows open roles right now.
Which of them have the largest teams?
By team size: SFA Therapeutics (4 employees) and Biocartesian (2 employees).
Which of them raised money recently?
Latest rounds: Myris Therapeutics — $500K Debt (Oct 2026), EpiVario — $185K Debt (Oct 2026), and Tolerance Bio — $15.1M Equity (Jun 2026).
Where are they based?
The biggest hubs are Philadelphia (8) and Pittsburgh (2).