Salus
Hiring
What they do:
Guardrails to validate your agent's actions before they execute
Quick facts:
HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 21 of 59
Orthogonal
Hiring
What they do:
Agentic Payments for APIs
Quick facts:
HQ: San Francisco, CA, United States
Ventura
Hiring
What they do:
AI Workforce for Distributors and Manufacturers
Quick facts:
HQ: San Francisco, CA, United States
Chasi
Hiring
What they do:
AI Revenue Engine for the Equipment Industry
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HQ: San Francisco, CA, United States
Tsenta
Hiring
What they do:
AI career agent that finds matching jobs & applies on your behalf
Quick facts:
HQ: San Francisco, CA, United States
MochaCare
Hiring
What they do:
Agentic Management Service for Care Organizations
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HQ: San Francisco, CA, United States
Hedge
Hiring
What they do:
AI-Native insurance company
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HQ: San Francisco, CA, United States
Replicas
Hiring
What they do:
Run any coding agent harness in the cloud
Quick facts:
HQ: San Francisco, CA, United States
Reason Machines
Hiring
What they do:
Reason Machines builds Reason Agent, the autonomous software engineer…
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HQ: San Francisco, CA, United States
Uno Wallet
Hiring
What they do:
The AI mobile wallet that replaces Apple Pay
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HQ: San Francisco, CA, United States
flowscope
Hiring
What they do:
AI implementation firm that maps and automates business processes
Quick facts:
HQ: San Francisco, CA, United States
HERA
Hiring
What they do:
We make sure every factory in the world builds without mistakes.
Quick facts:
HQ: San Francisco, CA, United States
Parasma
Hiring
What they do:
Replacing GPUs with human brain cells
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HQ: San Francisco, CA, United States
Rex
Hiring
What they do:
AI-native BPO for enterprise order-to-cash
Quick facts:
HQ: San Francisco, CA, United States
screenpipe
Hiring
What they do:
Turn your company's computer work into AI agents.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI collections agency for late stage portfolios
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HQ: San Francisco, CA, United States
Aktoria Robotics
Hiring
What they do:
Human as API for robots
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HQ: San Francisco, CA, United States
Rational
Hiring
What they do:
First Zero-human Accounting Firm
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HQ: San Francisco, CA, United States
Edviro
Hiring
What they do:
AI That Operates Energy Infrastructure
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HQ: San Francisco, CA, United States
Workers IO
Hiring
What they do:
Simulation Environments for Verifying Mission Critical Software
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HQ: San Francisco, CA, United States
Covera
Hiring
What they do:
AI-native OS for insurance brokers
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HQ: San Francisco, CA, United States
Vyra
Hiring
What they do:
Autonomous video editing for non-editors.
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HQ: San Francisco, CA, United States
What they do:
Quilt manages data like code so that companies can experiment faster
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HQ: San Francisco, CA, United States
What they do:
tEQuitable's mission is to create work culture that works for everyone
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HQ: San Francisco, CA, United States
What they do:
AI Accounting for Founders & Accountants
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HQ: San Francisco, CA, United States
What they do:
Virtual Co-working Community
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HQ: San Francisco, CA, United States
What they do:
One tool to supercharge your productivity.
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HQ: San Francisco, CA, United States
Blink
Hiring
What they do:
Build fully functional apps with AI.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Agentic workflows for complex, long running business operations
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HQ: San Francisco, CA, United States
What they do:
No-Code LLM Application / Workflow Builder
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HQ: San Francisco, CA, United States
What they do:
Limitless Real Estate
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HQ: San Francisco, CA, United States
What they do:
Frictionless payments via SMS
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HQ: San Francisco, CA, United States
What they do:
Scheduling software for digital health clinics to do more with less.
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HQ: San Francisco, CA, United States
What they do:
AI agents that automate AP, procurement, and finance
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HQ: San Francisco, CA, United States
What they do:
ai revenue engine for service businesses
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HQ: San Francisco, CA, United States
What they do:
Frontier models and agents you can learn from, audit, and steer.
Quick facts:
HQ: San Francisco, CA, United States