What they do:
Autonomous AI defense system for cyber attack
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HQ: San Francisco, CA, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 40 of 108
What they do:
OpenRouter for Voice AI: one API, every call on the best speech model
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HQ: San Francisco, CA, United States
What they do:
Modernizing Chip Manufacturing Infrastructure
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HQ: Ann Arbor, MI, United States
What they do:
AI-native procurement services for the physical economy
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HQ: San Francisco, CA, United States
What they do:
Least cost routing system to reduce 70%+ token spend
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HQ: San Francisco, CA, United States
What they do:
Unmanned cargo airplanes
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HQ: Los Angeles, CA, United States
What they do:
Unifying Global Private Credit
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HQ: San Francisco, CA, United States
What they do:
Turn Your Taste Into Hires
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HQ: San Francisco, CA, United States
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Automating away manual admin for food distributors: texts to ERP
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HQ: San Francisco, CA, United States
What they do:
AI agents that run onboarding, adoption, and renewals
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HQ: San Francisco, CA, United States
What they do:
Robots for high skilled labor powering AI infrastructure
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HQ: San Francisco, CA, United States
What they do:
Real-time cloud inference for robotics.
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HQ: San Francisco, CA, United States
What they do:
Enable robots to operate safely in the real world.
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HQ: San Francisco, CA, United States
What they do:
Super fast, unblockable browser infra for agents
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HQ: San Francisco, CA, United States
What they do:
Making the JVM faster
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HQ: San Francisco, CA, United States
What they do:
The neural engine for autonomous robots
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HQ: St. Louis, MO, United States
What they do:
Cursor for data analysis
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HQ: New York, NY, United States
What they do:
PowerRouter helps sales teams with lead routing in Salesforce
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HQ: Austin, TX, United States
What they do:
Analytics, built for the trades.
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HQ: San Francisco, CA, United States
What they do:
Natural hydrogel to keep internal organs scar-free after surgery
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HQ: Houston, TX, United States
What they do:
The easiest way to use AWS for agents and humans
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HQ: Dayton, OH, United States
What they do:
Real-time sales coach for SDRs
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HQ: New York, NY, United States
What they do:
Modern medical reference app for healthcare providers
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HQ: Minneapolis, MN, United States
What they do:
Easiest way to set up Zero Trust Access for your team
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HQ: San Francisco, CA, United States
What they do:
Zero-Knowledge security without seed phrases or backup codes
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HQ: Denver, CO, United States
What they do:
The AI growth marketer that turns SaaS signups into revenue
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HQ: San Francisco, CA, United States
What they do:
Helping physicians select the right therapy for breast cancer patients
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HQ: Austin, TX, United States
What they do:
Open source software that cleans and transforms messy healthcare data.
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HQ: Salt Lake City, UT, United States
What they do:
Automatically fill empty appointment slots for beauty professionals
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HQ: Orem, UT, United States
What they do:
A search technology that actually finds what you’re looking for.
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HQ: San Francisco, CA, United States
What they do:
Deploy serverless without rewriting code
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HQ: San Francisco, CA, United States
What they do:
AI-first user research platform
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HQ: San Francisco, CA, United States
What they do:
We build tools to help humanity predict the future.
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HQ: New York, NY, United States
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Platform to automate manual back-office work
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HQ: San Francisco, CA, United States
What they do:
Automating root cause analysis with generative AI
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HQ: New York, NY, United States
What they do:
Detect every data leak into third-party GenAI tools
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HQ: San Francisco, CA, United States