
Fifth Door
What they do:
Create and play games with AI
Quick facts:
HQ: San Francisco, CA, United States
This list has 2,003 startups and was last updated on Oct 15, 2026. 319 of them are hiring right now. Biggest hubs: San Francisco (868), New York (250), and Los Angeles (81). Largest teams: Breadfast, DoorDash, and Airbnb. Latest round: Scimplify raised $25M (Oct 15, 2026).
Survival statistics →1,163 open roles →

What they do:
Create and play games with AI
Quick facts:
HQ: San Francisco, CA, United States

What they do:
Anyone Can Trade
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HQ: San Francisco, CA, United States

What they do:
Indexing human dialogue through digital products
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HQ: San Francisco, CA, United States

What they do:
product lab. focused on personal ai and context.
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HQ: San Francisco, CA, United States

What they do:
AI agents that automate administrative work across college campuses.
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HQ: San Francisco, CA, United States

What they do:
The future of Social in the age of AI
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HQ: San Francisco, CA, United States

What they do:
Intelligent media storage for creative teams.
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HQ: New York, NY, United States

What they do:
AI healthcare concierge for employees
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HQ: New York, NY, United States

What they do:
AI Native Shopify
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HQ: San Francisco, CA, United States

What they do:
Talk to your computer without talking
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HQ: San Francisco, CA, United States

What they do:
The retreat where curious programmers recharge and grow
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HQ: New York, NY, United States

What they do:
We give Black software engineers support they need to advance in tech.
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HQ: San Francisco, CA, United States

What they do:
Buy flights for only a fraction upfront and pay off the rest in…
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HQ: Chicago, IL, United States

What they do:
Book guaranteed connecting rooms and suites at hotels
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HQ: San Francisco, CA, United States

What they do:
BloomAPI helps doctors share clinical data. Today most healthcare…
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HQ: Seattle, WA, United States

What they do:
App that turns selfie photos into thousand emoji that look like you…
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HQ: San Francisco, CA, United States

What they do:
Lucy’s mission is to reduce tobacco-related harm to zero. We provide…
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HQ: Los Angeles, CA, United States

What they do:
AI to curate your baby photos
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HQ: San Francisco, CA, United States

What they do:
Group-Therapy Platform for Providers and Health Systems
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HQ: San Francisco, CA, United States

What they do:
Dex is a personal CRM that reminds you to keep in touch with the…
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HQ: San Francisco, CA, United States

What they do:
Optimize your equity and taxes in real-time.
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HQ: San Francisco, CA, United States

What they do:
Fast and simple animation tool on the web 💫
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What they do:
Your AI co-worker
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HQ: San Francisco, CA, United States

What they do:
Making fast food faster
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HQ: Los Angeles, CA, United States

What they do:
The all-in-one screen recorder.
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HQ: Amsterdam, Netherlands

What they do:
Integrated, high touch healthcare — at scale
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HQ: New York, NY, United States

What they do:
Automating procurement and finance for construction companies
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HQ: New York, NY, United States

What they do:
Chime for Canada, starting with cash advances
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What they do:
Compound B2B SaaS for modern infrastructure to deploy and manage sites
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HQ: Atlanta, GA, United States

What they do:
US based USD accounts for non-US residents
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What they do:
A marketplace of luxury services for the ultra-wealthy
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HQ: Los Angeles, CA, United States

What they do:
Shopify for WhatsApp commerce
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HQ: Singapore

What they do:
AI-assitant for managing creator-brand partnerships
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HQ: Heidelberg, Germany

What they do:
Build AI influencers that autonomously create content, engage fans…
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HQ: San Francisco, CA, United States

What they do:
Recover failed subscription payments to increase retention and LTV
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HQ: Boston, MA, United States

What they do:
Reimagining education with short form video and AI
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HQ: New York, NY, United States