Top Startups in San Francisco

5 employeesYC X26Early stage

Logistics & supply chain Applied AI & ML Manufacturing & chips

Donkey

What they do:

The AI-native trading company: factory prices, delivered, one number

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5 employeesYC S26Early stage

Productivity & automation Applied AI & ML Robotics & drones

Zomma

What they do:

The AI BPO for financial servies, run by computer-use agents

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5 employeesYC S26Early stage

Cloud & infrastructure Applied AI & ML Developer tools

Riften

What they do:

Earned intelligence for every company

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5 employeesYC S26Early stage

Real estate & construction Applied AI & ML

Alloovium

What they do:

The company brain for construction companies

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5 employeesYC S26Early stage

Cerenovus

What they do:

AI that finds value creation opportunities across enterprise…

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5 employeesYC S26Early stage

Robotics & drones Manufacturing & chips

Nori

What they do:

The most capable American-made humanoid robot for $1,688

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5 employeesYC S26Early stage

Digital health & care Biotech & pharma

RonanRx Inc.

What they do:

Full Stack Pharmaceutical Company for Personalized Peptides and GLP-1s

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5 employeesYC S26Early stage

Applied AI & ML Cloud & infrastructure Manufacturing & chips

Operon

Hiring

What they do:

Agentic data layer for manufacturing & process industries.

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YC S26Early stage

Applied AI & ML Manufacturing & chips

Lamb Labs

Hiring

What they do:

Lightning fast chips with hardcoded AI models

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YC S26Early stage

Sales & marketing AI infrastructure & models Productivity & automation

Nex

What they do:

Grok bot for GTM & Revenue teams

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5 employeesYC S26Early stage

Applied AI & ML AI agents & assistants Cloud & infrastructure HR & recruiting

Sona8

What they do:

Context layer for enterprise AI surveying employees with voice agents

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5 employeesYC F26Early stage

Clean

What they do:

We tell sellers exactly when a company is ready to buy.

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5 employeesYC F26Early stage

HR & recruiting Insurance

Spine

Hiring

What they do:

We run benefits, payroll & compliance for startups, for free

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YC F26Early stage

Cybersecurity Applied AI & ML

DeepMark

What they do:

A live watermark inside AI voice that survives phone calls

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5 employeesYC F26Early stage

Productivity & automation

Screenleap

What they do:

One-click screen sharing with installation-free viewing on all devices

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4 employeesYC W12Early stageRemote

Biotech & pharma Manufacturing & chips Applied AI & ML

Synvivia

What they do:

Synvivia applies chemical control over cell behavior

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4 employeesYC S16Early stage

Medical devices & diagnostics Biotech & pharma Wellness & mental health

Clear Gene

What they do:

Our tests help eradicate cancer by telling doctors whether they got…

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4 employeesYC S18Early stage

Biotech & pharma Logistics & supply chain

Intact Therapeutics

What they do:

Smart gels for local drug delivery to the gut

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4 employeesYC W19Early stage

Applied AI & ML Biotech & pharma Manufacturing & chips Food & agriculture

Shiru

What they do:

Shiru leverages ML to create proteins to feed the world sustainably.

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4 employeesYC S19Early stage

Media & entertainment Education

Tappity

What they do:

World's largest library of interactive lessons for kids

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4 employeesYC S20Early stage

Applied AI & ML AI agents & assistants Food & agriculture E-commerce & retail

Avocado

What they do:

AI-Native Restaurant POS

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4 employeesYC W21Early stage

Seer

What they do:

Sell beyond the store.

E-commerce & retail

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4 employeesYC W21Early stageRemote

Digital health & care Wellness & mental health

Chorus Sleep

What they do:

Mobile app and coaching program that helps employees sleep better

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4 employeesYC W21Early stageRemote

Biotech & pharma Manufacturing & chips Climate & energy

BLUUMBIO

What they do:

We make bacteria and plants that clean up pollution.

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4 employeesYC S21Early stage

Digital health & care Biotech & pharma Wellness & mental health

REPROSENT

What they do:

Activating an overlooked force in medicine - the patient.

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4 employeesYC S21Early stageRemote

Infiuss Health

What they do:

2 sided Marketplace for accelerating medical research

Marketplaces

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4 employeesYC S21Early stage

Orca

What they do:

Banking for Gen Z, on steroids.

Banking & lending

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4 employeesYC W22Early stage

MosaicVoice

What they do:

We make it simple for call centers to automate quality assurance.

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4 employeesYC W22Early stageRemote

RefineTrain AI

What they do:

AI agents rewriting & optimising your internal documentation for LLMs

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4 employeesYC W22Early stageRemote

Applied AI & ML Data & analytics Sales & marketing

Siftly

What they do:

Get your brand discovered and recommended by ChatGPT

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4 employeesYC W22Early stage

Mobility & automotive Climate & energy Logistics & supply chain

Revoy

What they do:

Make diesel semi trucks hybrid-electric

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4 employeesYC W22Early stage

Applied AI & ML Legal, compliance & gov

Cobbery

What they do:

Superpowers for litigators

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4 employeesYC S22Early stage

Applied AI & ML Sales & marketing AI agents & assistants

Frigade

What they do:

AI-powered product assistance for modern software teams

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4 employeesYC W23Early stage

Media & entertainment Applied AI & ML

Shortbread

What they do:

Read romance comics.

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4 employeesYC W23Early stage

Applied AI & ML Cybersecurity Productivity & automation Legal, compliance & gov

Finic

What they do:

Frontier AI to stop fraud, abuse, and financial crimes.

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4 employeesYC W23Early stage