What they do:
Deploy Machine Learning Models with One Command
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HQ: San Francisco, CA, United States
Top Machine Learning Startups
This list has 243 startups and was last updated on Oct 15, 2026. 72 of them are hiring right now. Biggest hubs: San Francisco (128), New York (30), and London (11). Largest teams: Cruise, Relativity Space, and Flock Safety.
243 startupsPage 5 of 7
What they do:
Building a frontier world model for power
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HQ: Los Angeles, CA, United States
What they do:
AI agents to enroll providers with payors
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HQ: San Francisco, CA, United States
What they do:
Open source AI copilot that knows your company's code and its context
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HQ: San Francisco, CA, United States
What they do:
Open source agentic BI for founders
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HQ: San Francisco, CA, United States
What they do:
The best way to hire clinical talent.
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HQ: New York, NY, United States
What they do:
Simulation Engine for Benchmarking AI Products
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HQ: San Francisco, CA, United States
What they do:
Experiment tracking for training ML models
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HQ: London, United Kingdom
What they do:
The OS for data quality across any stack
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HQ: San Francisco, CA, United States
What they do:
Infra to build your own software factory
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HQ: New York, NY, United States
What they do:
The secure training data R&D engine for physical AI
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HQ: San Francisco, CA, United States
What they do:
Using VLMs to Catch Damage
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HQ: San Francisco, CA, United States
What they do:
The autonomous AI model factory
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HQ: San Francisco, CA, United States
What they do:
Foundation models on enterprise transaction data.
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HQ: San Francisco, CA, United States
What they do:
AI-Native Insurance for Frontier Tech
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HQ: San Francisco, CA, United States
What they do:
We find where AI agents fail, then train better models to run them.
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HQ: San Francisco, CA, United States
What they do:
The biggest crowdsourced benchmark for Computer-Use
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HQ: San Francisco, CA, United States
What they do:
World's Earliest Test for Alzheimer's Biomarkers
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HQ: San Francisco, CA, United States
What they do:
Connect with people around you—IRL
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HQ: Miami, FL, United States
What they do:
Digital AI humans that model clothes for e-commerce brands.
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HQ: New York, NY, United States
What they do:
Tools for the next era of physical automation.
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HQ: Germany
What they do:
Research lab solving non-verifiable work
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HQ: San Francisco, CA, United States
What they do:
Combining open-source AI models for better answers at lower cost
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HQ: San Francisco, CA, United States
What they do:
Online University for Tech Professionals
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HQ: San Francisco, CA, United States
What they do:
An AI agent for scientific research
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HQ: San Francisco, CA, United States
YC S24Early stage
What they do:
Engineering Intelligence and Token Optimization for the AI-Coding Era
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HQ: San Francisco, CA, United States
YC S26Early stage
Cruise
Acquired
What they do:
Self-driving cars.
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HQ: San Francisco, CA, United States
Pachama
Acquired
What they do:
Restoring nature to solve climate change.
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HQ: San Francisco, CA, United States
Pachyderm
Acquired
What they do:
Data Versioning, Data Pipelines, and Data Lineage
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HQ: San Francisco, CA, United States
Paperspace
Acquired
What they do:
Paperspace is a cloud platform for building and scaling AI…
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HQ: New York, NY, United States
Headstart
Acquired
What they do:
Headstart uses Machine Learning to help companies decide on who to…
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HQ: London, United Kingdom
Shelf Engine
Acquired
What they do:
Transforms how grocery stores buy highly perishable foods.
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HQ: Seattle, WA, United States
Quell
Acquired
What they do:
Get fit fighting your way through a fantasy world.
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HQ: London, United Kingdom
Replicate
Acquired
What they do:
Run machine learning models in the cloud
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HQ: San Francisco, CA, United States
Theorem
Acquired
What they do:
The mission of Theorem is to make credit safe and available. We use…
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HQ: San Francisco, CA, United States
AXDRAFT
Acquired
What they do:
AXDRAFT helps corporations draft, negotiate and approve documents 10x…
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HQ: Kyiv, Ukraine