What they do:
Government-funded online addiction treatment
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HQ: San Diego, CA, United States
Top Wellness Startups in California
This list has 131 startups and was last updated on Oct 15, 2026. 22 of them are hiring right now. Biggest hubs: San Francisco (121), Los Angeles (5), and San Diego (2). Largest teams: Truepill, Clipboard, and Tempo. Latest round: Malama Health raised $5.32M (Feb 26, 2026).
131 startupsPage 2 of 4
What they do:
Pediatric digital therapeutic for the +100M families in the US
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HQ: San Francisco, CA, United States
What they do:
Self-learning care for complex illness
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HQ: San Francisco, CA, United States
What they do:
One clinic for every sleep issue
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HQ: San Francisco, CA, United States
Reviving Mind
Hiring
What they do:
Addressing Loneliness and Isolation for Seniors
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HQ: San Francisco, CA, United States
Solum Health
Hiring
What they do:
AI Automation for Therapy Practices
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HQ: San Francisco, CA, United States
GloGlo
Hiring
What they do:
Curing and preventing type 1 diabetes
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HQ: San Francisco, CA, United States
Allia Health
Hiring
What they do:
AI-Native Medical Group for Mental Health
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HQ: San Francisco, CA, United States
What they do:
Group-Therapy Platform for Providers and Health Systems
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HQ: San Francisco, CA, United States
Deep24
Hiring
What they do:
AI coach for your entire life
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HQ: San Francisco, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
What they do:
We sequence your gut and build the probiotics it’s missing
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HQ: San Francisco, CA, United States
Rhem Labs
Hiring
What they do:
Home care technology for aging parents and their families
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HQ: San Francisco, CA, United States
What they do:
At-home oral health testing, coaching & care
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HQ: San Francisco, CA, United States
What they do:
Virtual Co-working Community
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HQ: San Francisco, CA, United States
What they do:
The personal coach and companion for cyclists.
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HQ: Truckee, CA, United States
What they do:
Elevated mRNA for transformative medicines.
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HQ: San Francisco, CA, United States
What they do:
A research lab for one
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HQ: San Francisco, CA, United States
What they do:
Enabling T cell immunotherapy discovery, development and manufacturing
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HQ: San Francisco, CA, United States
What they do:
The lifestyle medicine layer for clinicians.
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HQ: San Francisco, CA, United States
What they do:
We help people with chronic insomnia sleep better, using psychology.
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HQ: San Francisco, CA, United States
What they do:
At-cost preventive health: Labs, Scans, Genetics, Supplements and Rx
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HQ: San Francisco, CA, United States
What they do:
Adaptive training coach for runners, cyclists, and triathletes
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HQ: San Francisco, CA, United States
What they do:
Our tests help eradicate cancer by telling doctors whether they got…
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HQ: San Francisco, CA, United States
What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
What they do:
Activating an overlooked force in medicine - the patient.
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HQ: San Francisco, CA, United States
What they do:
Developing milk-inspired therapeutics for infectious diseases
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HQ: Davis, CA, United States
What they do:
An AI primary care doctor in your pocket
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HQ: San Francisco, CA, United States
What they do:
Our mobile app reduces chronic pain for 100 million Americans.
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HQ: Los Angeles, CA, United States
What they do:
AI Fitness Coach
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HQ: San Francisco, CA, United States
What they do:
24/7 Personal Health & Longevity Companion
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HQ: San Francisco, CA, United States
What they do:
AI nutrition coach in your pocket
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HQ: San Francisco, CA, United States
What they do:
Oura Ring for Skin
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HQ: San Francisco, CA, United States
What they do:
mRNA therapeutics to extend healthspan entering clinical trials
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HQ: San Francisco, CA, United States
What they do:
23andMe for environmental exposures
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HQ: San Francisco, CA, United States
What they do:
Enabling Tissue Targeting of Therapies
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HQ: San Francisco, CA, United States