What they do:
The AI workspace for software implementations
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HQ: San Francisco, CA, United States
Top AI & Data Startups in California
This list has 1,550 startups and was last updated on Oct 15, 2026. 481 of them are hiring right now. Biggest hubs: San Francisco (1,471), Los Angeles (51), and San Diego (5). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,550 startupsPage 29 of 44
What they do:
Physics-based foundation models for CAD optimization.
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HQ: San Francisco, CA, United States
What they do:
AI for quantitative trading
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HQ: San Francisco, CA, United States
What they do:
Turn maps into data
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HQ: San Francisco, CA, United States
What they do:
Self learning computer use agent for developers
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HQ: San Francisco, CA, United States
What they do:
Run open models as fast as your hardware allows
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HQ: San Francisco, CA, United States
What they do:
AI video editor
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HQ: San Francisco, CA, United States
What they do:
The continuous oversight engine for clinical trials
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HQ: San Francisco, CA, United States
What they do:
Building intellectually curious AI
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HQ: San Francisco, CA, United States
What they do:
Building tiny frontier AI models that run on edge devices
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HQ: San Francisco, CA, United States
What they do:
The boring stuff, handled. Everything else, supercharged.
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HQ: San Francisco, CA, United States
What they do:
The agentic debugger for AI systems
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HQ: San Francisco, CA, United States
What they do:
The Cursor for Chip Design - Delivering Silicon-Ready Chip Designs…
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HQ: San Francisco, CA, United States
What they do:
Your personal AI Assistant
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HQ: San Francisco, CA, United States
What they do:
Turns products into CLIs and agents into customers
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HQ: San Francisco, CA, United States
What they do:
Waymo for excavators
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HQ: San Francisco, CA, United States
What they do:
Planet-scale people discovery.
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HQ: San Francisco, CA, United States
What they do:
AI-native ERP for manufacturers
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HQ: San Francisco, CA, United States
What they do:
Synthetic populations for decisions
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HQ: San Francisco, CA, United States
What they do:
Automating regulatory submissions for life sciences
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HQ: San Francisco, CA, United States
What they do:
Payment infrastructure for AI agents
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HQ: San Francisco, CA, United States
What they do:
Find what's losing you customers and money in your AI agent and fix it
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HQ: San Francisco, CA, United States
What they do:
TikTok for Sports Trading
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HQ: San Francisco, CA, United States
What they do:
The OS for data quality across any stack
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HQ: San Francisco, CA, United States
What they do:
Delivering AI-powered situational awareness in tactical environments.
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HQ: San Francisco, CA, United States
What they do:
The sensitive data redaction layer for AI
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Platform Engineering
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HQ: San Francisco, CA, United States
What they do:
The control plane for AI agents.
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HQ: San Francisco, CA, United States
What they do:
A proactive desktop copilot. Clippy, but actually good.
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HQ: San Francisco, CA, United States
What they do:
AI language buddy in the games kids love
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HQ: San Francisco, CA, United States
What they do:
Self-tuning search for products and files
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HQ: San Francisco, CA, United States
What they do:
The coding agent that actually collaborates with you
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HQ: San Francisco, CA, United States
What they do:
Code and browse in the same place
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HQ: San Francisco, CA, United States
What they do:
The first platform where families can create AI cartoons in minutes
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HQ: San Francisco, CA, United States
What they do:
The first Agentic platform for Oncology
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HQ: San Francisco, CA, United States
What they do:
AI Legal OS
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HQ: Los Angeles, CA, United States