Thirdlayer
Hiring
What they do:
Continual learning for enterprise AI
Quick facts:
HQ: San Francisco, CA, United States
Top AI & Data Startups in San Francisco
This list has 1,471 startups and was last updated on Oct 15, 2026. 463 of them are hiring right now. Largest teams: Cruise, Fivetran, and Athelas. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
1,471 startupsPage 16 of 41
Chestnut
Hiring
What they do:
The first AI mortgage lender
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Specialized AI for Every Job
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HQ: San Francisco, CA, United States
MangoDesk
Hiring
What they do:
Long-horizon RL environments
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HQ: San Francisco, CA, United States
Humwork
Hiring
What they do:
Human experts as API for AI Agents
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HQ: San Francisco, CA, United States
Wedge
Hiring
What they do:
AI Employees for Healthcare
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HQ: San Francisco, CA, United States
OS3
Hiring
What they do:
Affordable, intelligent humanoid robots built to deploy at scale
Quick facts:
HQ: San Francisco, CA, United States
Alder
Hiring
What they do:
AI employees for finance, starting with accounts receivable.
Quick facts:
HQ: San Francisco, CA, United States
Unsiloed AI
Hiring
What they do:
API for parsing multimodal unstructured data
Quick facts:
HQ: San Francisco, CA, United States
Lemma
Hiring
What they do:
Production Monitoring for AI agents
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HQ: San Francisco, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
Waddle Labs
Hiring
What they do:
LLMs that control robots
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HQ: San Francisco, CA, United States
Payna
Hiring
What they do:
AI Licensing Agent for Regulated Industries
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HQ: San Francisco, CA, United States
What they do:
AI-native workspace for AEC
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HQ: San Francisco, CA, United States
Salus
Hiring
What they do:
Guardrails to validate your agent's actions before they execute
Quick facts:
HQ: San Francisco, CA, United States
Ventura
Hiring
What they do:
AI Workforce for Distributors and Manufacturers
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HQ: San Francisco, CA, United States
Fenrock AI
Hiring
What they do:
AI agents for banks
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HQ: San Francisco, CA, United States
Chasi
Hiring
What they do:
AI Revenue Engine for the Equipment Industry
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HQ: San Francisco, CA, United States
Tsenta
Hiring
What they do:
AI career agent that finds matching jobs & applies on your behalf
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HQ: San Francisco, CA, United States
MochaCare
Hiring
What they do:
Agentic Management Service for Care Organizations
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HQ: San Francisco, CA, United States
Hedge
Hiring
What they do:
AI-Native insurance company
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HQ: San Francisco, CA, United States
Discovered Materials
Hiring
What they do:
AI scientists to discover materials for the semiconductor industry.
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HQ: San Francisco, CA, United States
Uno Wallet
Hiring
What they do:
The AI mobile wallet that replaces Apple Pay
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HQ: San Francisco, CA, United States
flowscope
Hiring
What they do:
AI implementation firm that maps and automates business processes
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HQ: San Francisco, CA, United States
Parasma
Hiring
What they do:
Replacing GPUs with human brain cells
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HQ: San Francisco, CA, United States
Rex
Hiring
What they do:
AI-native BPO for enterprise order-to-cash
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HQ: San Francisco, CA, United States
IMPACT Drones
Hiring
What they do:
Air Defense as a Service for Civilian Infrastructure.
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HQ: San Francisco, CA, United States
screenpipe
Hiring
What they do:
Turn your company's computer work into AI agents.
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HQ: San Francisco, CA, United States
What they do:
AI collections agency for late stage portfolios
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HQ: San Francisco, CA, United States
Rational
Hiring
What they do:
First Zero-human Accounting Firm
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HQ: San Francisco, CA, United States
Edviro
Hiring
What they do:
AI That Operates Energy Infrastructure
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HQ: San Francisco, CA, United States
Workers IO
Hiring
What they do:
Simulation Environments for Verifying Mission Critical Software
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HQ: San Francisco, CA, United States
Covera
Hiring
What they do:
AI-native OS for insurance brokers
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HQ: San Francisco, CA, United States
What they do:
Quilt manages data like code so that companies can experiment faster
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HQ: San Francisco, CA, United States
What they do:
AI Accounting for Founders & Accountants
Quick facts:
HQ: San Francisco, CA, United States
Blink
Hiring
What they do:
Build fully functional apps with AI.
Quick facts:
HQ: San Francisco, CA, United States