Substrate
Hiring
What they do:
Artificial Intelligence for your medical billing team
Quick facts:
HQ: San Francisco, CA, United States
Top AI & Data Startups in the United States
This list has 2,134 startups and was last updated on Oct 15, 2026. 661 of them are hiring right now. Biggest hubs: San Francisco (1,471), New York (339), and Los Angeles (51). Largest teams: Cruise, Relativity Space, and Fivetran. Latest round: Safi Analytics raised $22.4M (Oct 14, 2026).
2,134 startupsPage 23 of 60
Mage Legal
Hiring
What they do:
Automatic AI Legal Diligence
Quick facts:
HQ: San Francisco, CA, United States
Zettascale Computing
Hiring
What they do:
Chips for frontier AI
Quick facts:
HQ: San Francisco, CA, United States
Rescript
Hiring
What they do:
AI for Legal & Public Policy Teams
Quick facts:
HQ: Washington, DC, United States
Candle
Hiring
What they do:
Candle helps friends and couples grow closer daily in just 5 minutes.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
The Localization Engineering Platform
Quick facts:
HQ: San Francisco, CA, United States
PermitPortal
Hiring
What they do:
AI Operating System for Pre-construction
Quick facts:
HQ: San Francisco, CA, United States
HumanLayer
Hiring
What they do:
The multiplayer control plane for your software factory
Quick facts:
HQ: San Francisco, CA, United States
Paragon
Hiring
What they do:
The AI Growth Engine for Industrials
Quick facts:
HQ: San Francisco, CA, United States
Atlog
Hiring
What they do:
Outbound voice and text AI without a prompt
Quick facts:
HQ: New York, NY, United States
CopyCat AI
Hiring
What they do:
AI for Commercial Insurance Agencies
Quick facts:
HQ: Seattle, WA, United States
Thirdlayer
Hiring
What they do:
Continual learning for enterprise AI
Quick facts:
HQ: San Francisco, CA, United States
Chestnut
Hiring
What they do:
The first AI mortgage lender
Quick facts:
HQ: San Francisco, CA, United States
Ralo
Hiring
What they do:
AI-Native Mortgage Broker
Quick facts:
HQ: New York, NY, United States
What they do:
Specialized AI for Every Job
Quick facts:
HQ: San Francisco, CA, United States
Alkali
Hiring
What they do:
The smarter way to estimate steel.
Quick facts:
HQ: Houston, TX, United States
MangoDesk
Hiring
What they do:
Long-horizon RL environments
Quick facts:
HQ: San Francisco, CA, United States
Humwork
Hiring
What they do:
Human experts as API for AI Agents
Quick facts:
HQ: San Francisco, CA, United States
CareSwift
Hiring
What they do:
AI scribe for Ambulance Reports
Quick facts:
HQ: New York, NY, United States
Wedge
Hiring
What they do:
AI Employees for Healthcare
Quick facts:
HQ: San Francisco, CA, United States
OneStop
Hiring
What they do:
The local internet for NYC.
Quick facts:
HQ: New York, NY, United States
OS3
Hiring
What they do:
Affordable, intelligent humanoid robots built to deploy at scale
Quick facts:
HQ: San Francisco, CA, United States
Flick
Hiring
What they do:
We Handle AI. You Direct Films.
Quick facts:
HQ: Santa Barbara, CA, United States
Alder
Hiring
What they do:
AI employees for finance, starting with accounts receivable.
Quick facts:
HQ: San Francisco, CA, United States
Unsiloed AI
Hiring
What they do:
API for parsing multimodal unstructured data
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Robotic factories that build robots
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HQ: Emeryville, CA, United States
Lemma
Hiring
What they do:
Production Monitoring for AI agents
Quick facts:
HQ: San Francisco, CA, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
Quick facts:
HQ: San Francisco, CA, United States
Waddle Labs
Hiring
What they do:
LLMs that control robots
Quick facts:
HQ: San Francisco, CA, United States
Payna
Hiring
What they do:
AI Licensing Agent for Regulated Industries
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI-native workspace for AEC
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HQ: San Francisco, CA, United States
Salus
Hiring
What they do:
Guardrails to validate your agent's actions before they execute
Quick facts:
HQ: San Francisco, CA, United States
Ventura
Hiring
What they do:
AI Workforce for Distributors and Manufacturers
Quick facts:
HQ: San Francisco, CA, United States
Laurence
Hiring
What they do:
Quantitative research for autonomous e-commerce growth
Quick facts:
HQ: New York, NY, United States
Fenrock AI
Hiring
What they do:
AI agents for banks
Quick facts:
HQ: San Francisco, CA, United States
Chasi
Hiring
What they do:
AI Revenue Engine for the Equipment Industry
Quick facts:
HQ: San Francisco, CA, United States