Uplane
Hiring
What they do:
Replace marketing agencies with AI
Quick facts:
HQ: San Francisco, CA, United States
Top AI Startups in San Francisco
This list has 1,355 startups and was last updated on Oct 15, 2026. 443 of them are hiring right now. Largest teams: Cruise, Athelas, and Checkr. Latest round: Litewave.AI raised $200K (Oct 7, 2026).
1,355 startupsPage 4 of 38
What they do:
Empowering women. Period.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
A new kind of power for finance teams
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HQ: San Francisco, CA, United States
Atomic
Hiring
What they do:
API that lets companies embed investment accounts into their services
Quick facts:
HQ: San Francisco, CA, United States
Mach9
Hiring
What they do:
AI CAD Software for Civil Engineering
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HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
Quick facts:
HQ: San Francisco, CA, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
Quick facts:
HQ: San Francisco, CA, United States
mdhub
Hiring
What they do:
AI-native operating system for behavioral health clinics.
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HQ: San Francisco, CA, United States
Ember
Hiring
What they do:
AI RCM. Increase net revenue by 16%.
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HQ: San Francisco, CA, United States
Harper
Hiring
What they do:
AI-native commercial insurance brokerage
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HQ: San Francisco, CA, United States
What they do:
The Javascript framework for building AI agents, from the Gatsby devs
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HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
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HQ: San Francisco, CA, United States
What they do:
Handl converts documents (invoices, income stabs, custom forms, etc.)…
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HQ: San Francisco, CA, United States
HUD
Hiring
What they do:
Platform and marketplace for RL environments and AI data
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Replika is an AI friend that you can talk to designed to make you…
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HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
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HQ: San Francisco, CA, United States
Respan
Hiring
What they do:
Self-driving observability, evals, and gateway for AI agents
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HQ: San Francisco, CA, United States
Datrics
Hiring
What they do:
Generative AI Healthcare Coding Automation
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HQ: San Francisco, CA, United States
Entangl
Hiring
What they do:
Find & resolve issues in data center engineering & operations using AI
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HQ: San Francisco, CA, United States
Strada
Hiring
What they do:
AI agents that run insurance operations
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HQ: San Francisco, CA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
Replo
Hiring
What they do:
Sell anything
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HQ: San Francisco, CA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
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HQ: San Francisco, CA, United States
OneSchema
Hiring
What they do:
The AI Cowork for big data
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HQ: San Francisco, CA, United States
What they do:
We make Orca, MIT open source terminal-based agent orchestrator
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HQ: San Francisco, CA, United States
Gym Class
Hiring
What they do:
Connecting the world by simulating it
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HQ: San Francisco, CA, United States
loopfour
Hiring
What they do:
Workflow automation, without AI hallucinations.
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HQ: San Francisco, CA, United States
LiteLLM
Hiring
What they do:
Call every LLM API like it's OpenAI [100+ LLMs]
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HQ: San Francisco, CA, United States
Readily
Hiring
What they do:
AI Compliance Platform for Healthcare Organizations
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HQ: San Francisco, CA, United States
FleetWorks
Hiring
What they do:
AI enabled marketplace matching trucks with jobs
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HQ: San Francisco, CA, United States
Tamarind Bio
Hiring
What they do:
AI Inference Platform for Drug Discovery
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HQ: San Francisco, CA, United States
Contrario
Hiring
What they do:
AI hiring platform powered by expert recruiters
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HQ: San Francisco, CA, United States
AgileMD
Hiring
What they do:
Predictive analytics and clinical pathways for hospitals
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HQ: San Francisco, CA, United States
What they do:
The fastest way to ship airtight AI
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HQ: San Francisco, CA, United States
JITX
Hiring
What they do:
Automatic circuit board design.
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HQ: San Francisco, CA, United States
What they do:
The fashion product engineering intelligence
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HQ: San Francisco, CA, United States