Quick facts:
HQ: Cambridge, MA, United States
Incorporated: 2025
Funding:
$1M · SAFE · May 2026
Top B2B Software Startups in Massachusetts
This list has 99 startups and was last updated on Oct 15, 2026. 6 of them are hiring right now. Biggest hubs: Boston (65), Cambridge (13), and Burlington (3). Largest teams: Ginkgo Bioworks, TetraScience, and Cloudant. Latest round: Arkea Bio raised $15M (Oct 9, 2026).
99 startupsPage 3 of 3
Quick facts:
HQ: Watertown, MA, United States
Incorporated: 2025
Funding:
$970K · Equity · Oct 2026
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HQ: Burlington, MA, United States
Incorporated: 2025
Funding:
$238K · Equity · Oct 2026
Quick facts:
HQ: Boston, MA, United States
Incorporated: 2025
Funding:
$100K · SAFE · Oct 2026
Cloudant
Acquired
What they do:
NoSQL Database-aaS. Acquired by IBM in 2014. Now IBM Cloud Data…
Quick facts:
HQ: Boston, MA, United States
Vendr
Acquired
What they do:
The AI negotiation agent to help you save money on SaaS.
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HQ: Boston, MA, United States
Sandbox Banking
Acquired
What they do:
Low-code integration platform for banking
Quick facts:
HQ: Boston, MA, United States
Moltin
Acquired
What they do:
eCommerce building blocks through simple APIs for websites & apps.…
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HQ: Boston, MA, United States
Ascen
Acquired
What they do:
EOR for the staffing industry
Quick facts:
HQ: Boston, MA, United States
Impactive (formerly Outvote)
Acquired
What they do:
Political/civic tech helping progressive campaigns organize & mobilize
Quick facts:
HQ: Boston, MA, United States
Gaiascope
Acquired
What they do:
SaaS that helps renewables & energy storage operate more profitably
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HQ: Boston, MA, United States
Pretty Instant
Acquired
What they do:
Inventor of the first roaming-photo booth + pro photography platform
Quick facts:
HQ: Boston, MA, United States
Bytebot
Acquired
What they do:
Bytebot is the open source container for AI desktop agents.
Quick facts:
HQ: Boston, MA, United States
Embedly
Acquired
What they do:
Embedly provides a platform and suite of tools to make embedding and previewing links simple. Embedly helps publishers and consumers manage embed codes from…
Quick facts:
HQ: Boston, MA, United States
Kiko
Acquired
What they do:
We're the best online calendar solution to ever exist. Period.
Quick facts:
HQ: Boston, MA, United States
YC S05Early stage
Hunter2
Acquired
What they do:
Hunter2 trains engineering teams in application security through…
Quick facts:
HQ: Boston, MA, United States
YC W18Early stage
Mindmesh
Shut down
What they do:
Mindmesh is the virtual desk that puts you in control.
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HQ: Boston, MA, United States
Ubiq
Shut down
What they do:
Screen-sharing for enterprise conference rooms
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HQ: Boston, MA, United States
Goodly
Shut down
What they do:
Student loan repayment as an employee benefit.
Quick facts:
HQ: Boston, MA, United States
WireOver
Shut down
What they do:
Really secure file sending for big files.
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HQ: Boston, MA, United States
Hipmob
Shut down
What they do:
Customer communication for iOS and Android developers - an in-app…
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HQ: Boston, MA, United States
DevFlight
Shut down
What they do:
Managed equipment data pipelines for manufacturers
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HQ: Boston, MA, United States
Bensen
Shut down
What they do:
Online and phone ordering for restaurant takeout and delivery
Quick facts:
HQ: Boston, MA, United States
CO2Stats
Shut down
What they do:
Social and environmental web analytics. Acquired in December 2016.
Quick facts:
HQ: Boston, MA, United States
YC S08Early stage
Audiobeta
Shut down
What they do:
AudioBeta develops web-based applications that helps bands communicate with fans and make informed decisions when planning tours. AudioBeta is a U.S.-based…
Quick facts:
HQ: Boston, MA, United States
YC W06Early stage
Memamp
Shut down
What they do:
Better Desktop search solution.
Quick facts:
HQ: Boston, MA, United States
YC S05Early stage
Eivod
Shut down
Quick facts:
HQ: Boston, MA, United States