Quick facts:
HQ: Cambridge, MA, United States
Incorporated: 2022
Funding:
$20M · Equity · Apr 2026
Top B2B Software Startups in Massachusetts
This list has 99 startups and was last updated on Oct 15, 2026. 6 of them are hiring right now. Biggest hubs: Boston (65), Cambridge (13), and Burlington (3). Largest teams: Ginkgo Bioworks, TetraScience, and Cloudant. Latest round: Arkea Bio raised $15M (Oct 9, 2026).
99 startupsPage 2 of 3
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HQ: Boston, MA, United States
Funding:
$20M · Equity · Jan 2026
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HQ: Charlestown, MA, United States
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$15M · Equity · Oct 2026
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HQ: Cambridge, MA, United States
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$14.4M · Equity · Apr 2026
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HQ: Boston, MA, United States
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$13.4M · Equity · Jan 2026
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HQ: Boston, MA, United States
Incorporated: 2021
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$13.2M · Equity · Apr 2026
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HQ: Cambridge, MA, United States
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$12.8M · Equity · May 2026
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HQ: Boston, MA, United States
Incorporated: 2021
Funding:
$11.7M · Equity · Jun 2026
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HQ: Sutton, MA, United States
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$11.5M · Equity · Apr 2026
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HQ: Boston, MA, United States
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$11.3M · Equity · Jan 2026
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HQ: Boston, MA, United States
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$11.3M · Equity · Jan 2026
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HQ: Cambridge, MA, United States
Incorporated: 2025
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$8.76M · Equity · Mar 2026
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HQ: Cambridge, MA, United States
Incorporated: 2023
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$8.63M · Equity · Apr 2026
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HQ: Cambridge, MA, United States
Incorporated: 2024
Funding:
$8M · Equity · Apr 2026
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HQ: Cambridge, MA, United States
Incorporated: 2022
Funding:
$8M · Options · May 2026
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HQ: Concord, MA, United States
Incorporated: 2025
Funding:
$7.96M · Equity · Apr 2026
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HQ: Needham, MA, United States
Incorporated: 2025
Funding:
$7.5M · Debt · Apr 2026
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HQ: Cambridge, MA, United States
Incorporated: 2025
Funding:
$7.16M · Equity · Oct 2026
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HQ: Cambridge, MA, United States
Incorporated: 2022
Funding:
$7M · Equity · Jun 2026
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HQ: Cambridge, MA, United States
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$5.7M · Equity · May 2026
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HQ: Marlborough, MA, United States
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$5M · Debt · Jun 2026
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HQ: Weston, MA, United States
Incorporated: 2022
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$4.8M · Equity · Jan 2026
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HQ: Somerville, MA, United States
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$3.96M · Equity · Oct 2026
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HQ: Groton, MA, United States
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$3.52M · Equity · Mar 2026
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HQ: Cambridge, MA, United States
Incorporated: 2023
Funding:
$3M · Equity · Mar 2026
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HQ: Austin, MA, United States
Incorporated: 2025
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$2.9M · Equity · Mar 2026
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HQ: Boston, MA, United States
Incorporated: 2023
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$2.8M · Equity · Feb 2026
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HQ: Lowell, MA, United States
Incorporated: 2022
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$2.5M · Options · Jun 2026
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HQ: Hingham, MA, United States
Incorporated: 2026
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$2.39M · Equity · Mar 2026
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HQ: Lexington, MA, United States
Incorporated: 2024
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$2.2M · Equity · May 2026
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HQ: Amherst, MA, United States
Incorporated: 2021
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$2.09M · Equity · Mar 2026
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HQ: Boston, MA, United States
Incorporated: 2023
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$2.06M · Equity · Feb 2026
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HQ: Boston, MA, United States
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$1.8M · Equity · Oct 2026
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HQ: Boston, MA, United States
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$1.5M · SAFE · Mar 2026
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HQ: Norwood, MA, United States
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$1.3M · Equity · Jan 2026
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HQ: Boston, MA, United States
Incorporated: 2023
Funding:
$1.28M · Debt · Apr 2026