What they do:
Motor cortex for physical AI
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HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 30 of 59
What they do:
Continuous optimization for AI agents
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HQ: San Francisco, CA, United States
What they do:
The managed cloud for AI agents.
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HQ: San Francisco, CA, United States
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Simple third-party app patching and deployment for Windows.
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HQ: San Francisco, CA, United States
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Virtualmin is taking on the lack of innovation in the server admin programs, like Plesk, by making a more accessable version for pages managed by the…
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HQ: San Francisco, CA, United States
What they do:
The 401(k) that helps you grow
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HQ: San Francisco, CA, United States
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Online circuit simulator and electronic schematic editor.
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HQ: San Francisco, CA, United States
What they do:
Fastest, easiest, and most affordable way for small business owners…
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HQ: San Francisco, CA, United States
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The Self-Hosting Company
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HQ: San Francisco, CA, United States
What they do:
Easy button to use data for your daily operations
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HQ: San Francisco, CA, United States
What they do:
Subscriptions for neighborhood businesses
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HQ: San Francisco, CA, United States
What they do:
Marketplace for small business M&A
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HQ: San Francisco, CA, United States
What they do:
AI to track and analyze public policy
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HQ: San Francisco, CA, United States
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Conversational AI assistants using your knowledge
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HQ: San Francisco, CA, United States
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Sequin is building AI Voice Agents to automate collections calls for…
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HQ: San Francisco, CA, United States
What they do:
Automated phone ordering system for restaurants
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HQ: San Francisco, CA, United States
What they do:
Connect LinkedIn to your CRM to automate and track LinkedIn outreach.
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HQ: San Francisco, CA, United States
What they do:
AI Search for the Next Generation
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HQ: San Francisco, CA, United States
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AI agents to build B2B datasets
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HQ: San Francisco, CA, United States
What they do:
The best AI chat you've ever used
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HQ: San Francisco, CA, United States
What they do:
Intelligent Customer Implementation Platform for B2B
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HQ: San Francisco, CA, United States
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AI-powered engineering productivity tools
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HQ: San Francisco, CA, United States
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Your autonomous motion designer that turns every feature into a…
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HQ: San Francisco, CA, United States
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AI coding copilot engineered for performance
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HQ: San Francisco, CA, United States
What they do:
Deploy Machine Learning Models with One Command
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HQ: San Francisco, CA, United States
What they do:
AI Teammates for Data Tasks
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HQ: San Francisco, CA, United States
What they do:
Your self-generating, self-maintaining code knowledge base.
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HQ: San Francisco, CA, United States
What they do:
Product design tool that lets everyone design like a designer
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HQ: San Francisco, CA, United States
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Single source of truth for your clinic's finances and supply chain.
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HQ: San Francisco, CA, United States
What they do:
The ultimate IP assistant.
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HQ: San Francisco, CA, United States
What they do:
Network Intelligence for Investors
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HQ: San Francisco, CA, United States
What they do:
Program computers with natural language
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HQ: San Francisco, CA, United States
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Screen recorder for stunning product demo videos
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HQ: San Francisco, CA, United States
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CRM Co-Pilot for Medtech Sales
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HQ: San Francisco, CA, United States
What they do:
Build a website by chatting with AI
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Enterprises
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HQ: San Francisco, CA, United States