What they do:
AI-native ERP for manufacturers
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HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 34 of 59
What they do:
Synthetic populations for decisions
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HQ: San Francisco, CA, United States
What they do:
Automating regulatory submissions for life sciences
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HQ: San Francisco, CA, United States
What they do:
Payment infrastructure for AI agents
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HQ: San Francisco, CA, United States
What they do:
Find what's losing you customers and money in your AI agent and fix it
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HQ: San Francisco, CA, United States
What they do:
The Routing Layer for AI Agents
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HQ: San Francisco, CA, United States
What they do:
Identify churn risk and stay close to users at scale
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HQ: San Francisco, CA, United States
What they do:
The OS for data quality across any stack
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HQ: San Francisco, CA, United States
What they do:
AI Tax prep and accounting software for CPA firms
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HQ: San Francisco, CA, United States
What they do:
Delivering AI-powered situational awareness in tactical environments.
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HQ: San Francisco, CA, United States
What they do:
The sensitive data redaction layer for AI
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Platform Engineering
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HQ: San Francisco, CA, United States
What they do:
The control plane for AI agents.
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HQ: San Francisco, CA, United States
What they do:
A proactive desktop copilot. Clippy, but actually good.
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HQ: San Francisco, CA, United States
What they do:
Self-tuning search for products and files
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HQ: San Francisco, CA, United States
What they do:
The coding agent that actually collaborates with you
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HQ: San Francisco, CA, United States
What they do:
Code and browse in the same place
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HQ: San Francisco, CA, United States
What they do:
AI support done right
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HQ: San Francisco, CA, United States
What they do:
Real-time web intelligence API for AI agents and GTM teams
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HQ: San Francisco, CA, United States
What they do:
Canva for short-form video ads
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HQ: San Francisco, CA, United States
What they do:
AI plug-in that automates HR immigration screening and compliance
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HQ: San Francisco, CA, United States
What they do:
Use Claude Code at 47% less cost in one line of installation.
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HQ: San Francisco, CA, United States
What they do:
AI that automatically improves products from user behavior
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HQ: San Francisco, CA, United States
What they do:
Claude Code for Mechanical Engineers
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HQ: San Francisco, CA, United States
What they do:
Datadog for Agent Reliability
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HQ: San Francisco, CA, United States
What they do:
Real time intelligence for law enforcement & security teams.
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HQ: San Francisco, CA, United States
What they do:
Detect what AI can automate for your team
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HQ: San Francisco, CA, United States
What they do:
AI teammates for logistics
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HQ: San Francisco, CA, United States
What they do:
Turning all software into agent-first APIs
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HQ: San Francisco, CA, United States
What they do:
Notion for AI chats
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HQ: San Francisco, CA, United States
What they do:
Enterprise post-training, monitoring, and continual learning platform
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HQ: San Francisco, CA, United States
What they do:
AI models that learn from experience
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HQ: San Francisco, CA, United States
What they do:
AI SRE agent that triages, coordinates, and fixes production incidents
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HQ: San Francisco, CA, United States
What they do:
AI agents that automate B2B software implementation
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HQ: San Francisco, CA, United States
What they do:
Scaling formal verification to accelerate scientific discovery
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HQ: San Francisco, CA, United States
What they do:
Infrastructure for Autonomous Science
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HQ: San Francisco, CA, United States