What they do:
#1 easiest-to-use payroll for startups
Quick facts:
HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 7 of 59
Beacons
Hiring
What they do:
An AI-powered, all-in-one business platform for content creators
Quick facts:
HQ: San Francisco, CA, United States
What they do:
A new kind of power for finance teams
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HQ: San Francisco, CA, United States
Seam
Hiring
What they do:
API for IoT Devices
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HQ: San Francisco, CA, United States
Atomic
Hiring
What they do:
API that lets companies embed investment accounts into their services
Quick facts:
HQ: San Francisco, CA, United States
Terra API
Hiring
What they do:
API for developers and AIs to access health data
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HQ: San Francisco, CA, United States
What they do:
The #1 Market Network for Government Contractors.
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HQ: San Francisco, CA, United States
testRigor
Hiring
What they do:
Executable specifications in English for test automation
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HQ: San Francisco, CA, United States
Mach9
Hiring
What they do:
AI CAD Software for Civil Engineering
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HQ: San Francisco, CA, United States
What they do:
AI-Native Spend platform built for Real Estate businesses
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HQ: San Francisco, CA, United States
CodeAnt AI
Hiring
What they do:
Autonomous offensive and defensive cybersecurity platform
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HQ: San Francisco, CA, United States
What they do:
The Javascript framework for building AI agents, from the Gatsby devs
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HQ: San Francisco, CA, United States
Apero Health
Hiring
What they do:
Modern medical billing
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HQ: San Francisco, CA, United States
What they do:
Handl converts documents (invoices, income stabs, custom forms, etc.)…
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HQ: San Francisco, CA, United States
HUD
Hiring
What they do:
Platform and marketplace for RL environments and AI data
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HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
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HQ: San Francisco, CA, United States
What they do:
Platform that allows anyone to create and monetize video games.
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HQ: San Francisco, CA, United States
Respan
Hiring
What they do:
Self-driving observability, evals, and gateway for AI agents
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HQ: San Francisco, CA, United States
Canix
Hiring
What they do:
Canix makes it easy to get and stay compliant as a cannabis business.
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HQ: San Francisco, CA, United States
Datrics
Hiring
What they do:
Generative AI Healthcare Coding Automation
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HQ: San Francisco, CA, United States
Entangl
Hiring
What they do:
Find & resolve issues in data center engineering & operations using AI
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HQ: San Francisco, CA, United States
Tandem
Hiring
What they do:
AI-native office leasing broker
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HQ: San Francisco, CA, United States
Pulse
Hiring
What they do:
Production-grade unstructured document extraction
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HQ: San Francisco, CA, United States
IOMETE
Hiring
What they do:
Self-hosted data lakehouse platform
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HQ: San Francisco, CA, United States
Strada
Hiring
What they do:
AI agents that run insurance operations
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HQ: San Francisco, CA, United States
Castle
Hiring
What they do:
Block bots & bad behavior
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HQ: San Francisco, CA, United States
What they do:
Just-in-time training and communication for frontline healthcare teams
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HQ: San Francisco, CA, United States
Nestor
Hiring
What they do:
Skills-based talent management solutions for a dynamic workforce.
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HQ: San Francisco, CA, United States
Accord
Hiring
What they do:
The Revenue Excellence Platform
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HQ: San Francisco, CA, United States
Swif.ai
Hiring
What they do:
Manage every device. Govern every AI agent.
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HQ: San Francisco, CA, United States
Replo
Hiring
What they do:
Sell anything
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HQ: San Francisco, CA, United States
OneSchema
Hiring
What they do:
The AI Cowork for big data
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HQ: San Francisco, CA, United States
What they do:
We make Orca, MIT open source terminal-based agent orchestrator
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HQ: San Francisco, CA, United States
Medplum
Hiring
What they do:
API first electronic health record (EHR) that is open source
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HQ: San Francisco, CA, United States
loopfour
Hiring
What they do:
Workflow automation, without AI hallucinations.
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HQ: San Francisco, CA, United States
LiteLLM
Hiring
What they do:
Call every LLM API like it's OpenAI [100+ LLMs]
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HQ: San Francisco, CA, United States