What they do:
Specialized models that make your AI agents cheaper and more reliable.
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HQ: San Francisco, CA, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 53 of 108
What they do:
Company brain that powers your AI employees
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HQ: San Francisco, CA, United States
What they do:
The AI Workforce for Biopharma
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HQ: San Francisco, CA, United States
What they do:
OpenRouter for Agent Tools
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HQ: San Francisco, CA, United States
What they do:
The first AI founder: a virtual human who runs his own companies.
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HQ: San Francisco, CA, United States
What they do:
The IDE for Tokenmaxxers
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HQ: Boston, MA, United States
What they do:
Co-designing the fastest intelligence
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HQ: San Francisco, CA, United States
What they do:
AI For The Skilled Workforce
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HQ: San Francisco, CA, United States
What they do:
Effortlessly deploy cloud software factories.
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HQ: San Francisco, CA, United States
What they do:
We make law firms AI-native.
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HQ: San Francisco, CA, United States
What they do:
Your personal context, securely portable across every AI app.
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HQ: San Francisco, CA, United States
What they do:
Crafting simulations for frontier lab model training
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HQ: San Francisco, CA, United States
What they do:
The autonomous AI model factory
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HQ: San Francisco, CA, United States
What they do:
AI FDE that deploys custom AI agents into ERPs
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HQ: San Francisco, CA, United States
What they do:
Making Diamond Semiconductors
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HQ: San Francisco, CA, United States
What they do:
Simulating Agents Running Industrial Companies
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HQ: San Francisco, CA, United States
What they do:
Accurately simulate market response at scale
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HQ: San Francisco, CA, United States
What they do:
A cloud devbox that feels local
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HQ: San Francisco, CA, United States
What they do:
Self-optimizing neocloud that cuts LLM costs by 100x
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HQ: San Francisco, CA, United States
What they do:
AI Agents to Make Local Gov Efficient
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HQ: San Francisco, CA, United States
What they do:
Foundation models on enterprise transaction data.
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HQ: San Francisco, CA, United States
What they do:
AI-native OS for Real Estate Brokerages
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HQ: San Francisco, CA, United States
What they do:
OpenClaw for manufacturers
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HQ: San Francisco, CA, United States
What they do:
Defining the frontier of multiplayer AI.
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HQ: San Francisco, CA, United States
What they do:
Market for future inference capacity
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HQ: San Francisco, CA, United States
What they do:
AI-powered freight brokerage. Quote, book, and track loads in seconds.
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HQ: San Francisco, CA, United States
What they do:
CrowdStrike for AI Agents
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HQ: San Francisco, CA, United States
What they do:
Quant Neolab building self-improving agents from quant data
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HQ: San Francisco, CA, United States
What they do:
AI-native freight brokerage
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HQ: San Francisco, CA, United States
What they do:
AI for Construction's Back Office
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HQ: San Francisco, CA, United States
What they do:
AI Operating System for Wholesale Distribution
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HQ: San Francisco, CA, United States
What they do:
Databricks for Enterprise Codebases
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HQ: San Francisco, CA, United States
What they do:
Legora for AEC (Architecture, Engineering, & Construction) firms
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HQ: San Francisco, CA, United States
What they do:
The world's frontier hacker of AI agents.
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HQ: San Francisco, CA, United States
What they do:
Legora for commercial insurance carriers
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HQ: San Francisco, CA, United States
What they do:
AI-Native Insurance for Frontier Tech
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HQ: San Francisco, CA, United States