What they do:
AI platform accelerating therapies for rare & inflammatory diseases.
Quick facts:
HQ: San Francisco, CA, United States
YC S19Early stage
Top Biotech Startups in California
This list has 199 startups and was last updated on Oct 15, 2026. 21 of them are hiring right now. Biggest hubs: San Francisco (134), San Diego (14), and Irvine (5). Largest teams: Benchling, BillionToOne, and Ansa Biotechnologies. Latest round: Renue Life Sciences raised $250K (Oct 14, 2026).
199 startupsPage 4 of 6
What they do:
An AI agent for scientific research
Quick facts:
HQ: San Francisco, CA, United States
YC S24Early stage
What they do:
The full-stack AI CRO for drug discovery.
Quick facts:
HQ: San Francisco, CA, United States
YC F26Early stage
Quick facts:
HQ: Emeryville, CA, United States
Funding:
$134M · Options · Jan 2026
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HQ: South San Francisco, CA, United States
Incorporated: 2021
Funding:
$125M · Equity · Jun 2026
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HQ: South San Francisco, CA, United States
Funding:
$115M · Equity · Jun 2026
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HQ: Foster City, CA, United States
Funding:
$75.9M · Equity · Jun 2026
Quick facts:
HQ: South San Francisco, CA, United States
Funding:
$75M · Equity · Jun 2026
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HQ: Foster City, CA, United States
Funding:
$68.5M · Equity · Jan 2026
Quick facts:
HQ: Palo Alto, CA, United States
Incorporated: 2024
Funding:
$62M · Equity · Mar 2026
Quick facts:
HQ: South San Francisco, CA, United States
Incorporated: 2022
Funding:
$40.7M · Equity · Apr 2026
Quick facts:
HQ: Menlo Park, CA, United States
Funding:
$40M · Equity · Mar 2026
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HQ: San Carlos, CA, United States
Incorporated: 2024
Funding:
$30.7M · Equity · Mar 2026
Quick facts:
HQ: San Diego, CA, United States
Funding:
$27.8M · Equity · Apr 2026
Quick facts:
HQ: South San Francisco, CA, United States
Funding:
$27.1M · Equity · Apr 2026
Quick facts:
HQ: San Diego, CA, United States
Funding:
$26M · Options · Jan 2026
Quick facts:
HQ: San Carlos, CA, United States
Incorporated: 2023
Funding:
$21.1M · Equity · Jan 2026
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HQ: San Diego, CA, United States
Funding:
$19.5M · Equity · Jun 2026
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HQ: Carlsbad, CA, United States
Incorporated: 2023
Funding:
$19.1M · Equity · Jun 2026
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HQ: Solana Beach, CA, United States
Funding:
$17.9M · Equity · Feb 2026
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HQ: Novato, CA, United States
Incorporated: 2022
Funding:
$15.2M · Equity · May 2026
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HQ: San Francisco, CA, United States
Incorporated: 2025
Funding:
$15M · Equity · Jun 2026
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HQ: San Francisco, CA, United States
Incorporated: 2023
Funding:
$14.8M · Equity · Apr 2026
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HQ: Palo Alto, CA, United States
Incorporated: 2025
Funding:
$13.5M · Equity + debt · Apr 2026
Quick facts:
HQ: San Francisco, CA, United States
Incorporated: 2024
Funding:
$13.2M · Equity · Mar 2026
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HQ: Irvine, CA, United States
Funding:
$12M · SAFE · Jun 2026
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HQ: Irvine, CA, United States
Incorporated: 2023
Funding:
$11.5M · Equity · May 2026
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HQ: San Diego, CA, United States
Incorporated: 2022
Funding:
$11.4M · Equity · Sep 2026
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HQ: Solana Beach, CA, United States
Funding:
$11M · Equity · Apr 2026
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HQ: Torrance, CA, United States
Funding:
$10.3M · Debt · May 2026
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HQ: Los Altos, CA, United States
Incorporated: 2025
Funding:
$10M · Equity + debt · Mar 2026
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HQ: Mountain View, CA, United States
Funding:
$10M · Equity · Apr 2026
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HQ: San Francisco, CA, United States
Incorporated: 2025
Funding:
$9.65M · Equity · Apr 2026
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HQ: San Diego, CA, United States
Funding:
$8.97M · Options · Oct 2026
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HQ: West Sacramento, CA, United States
Funding:
$8.06M · Equity · Feb 2026
Quick facts:
HQ: San Francisco, CA, United States
Funding:
$7.75M · Equity · Sep 2026