What they do:
Evolutionary intelligence for autoimmune disease
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HQ: San Francisco, CA, United States
Top Biotech Startups in California
This list has 199 startups and was last updated on Oct 15, 2026. 21 of them are hiring right now. Biggest hubs: San Francisco (134), San Diego (14), and Irvine (5). Largest teams: Benchling, BillionToOne, and Ansa Biotechnologies. Latest round: Renue Life Sciences raised $250K (Oct 14, 2026).
199 startupsPage 3 of 6
What they do:
YourChoice therapeutics is revolutionizing the contraceptive market…
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HQ: San Francisco, CA, United States
What they do:
We build better immunotherapies
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HQ: San Francisco, CA, United States
What they do:
Creating a New Class of Drugs to Address Incurable Autoimmune Diseases
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HQ: Irvine, CA, United States
What they do:
Growing micro-organs to find new drugs
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HQ: San Francisco, CA, United States
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Engineering microbes for miners to unlock billions in trapped metal
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HQ: San Francisco, CA, United States
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24/7 Personal Health & Longevity Companion
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HQ: San Francisco, CA, United States
What they do:
Extrapolative AI to unlock First-in-Class drugs
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HQ: San Francisco, CA, United States
What they do:
AI-native CRO for clinical trial operations
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HQ: San Francisco, CA, United States
What they do:
AI-native pharma company
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HQ: San Francisco, CA, United States
What they do:
Making chemicals 100,000x faster
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HQ: San Francisco, CA, United States
What they do:
Embodied Scientific Intelligence
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HQ: San Francisco, CA, United States
What they do:
Tradewind translates scientific insight into innovative ways of…
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HQ: San Francisco, CA, United States
What they do:
Synkrino's AI, SATIS is a powerful, unbiased discovery system for…
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HQ: San Francisco, CA, United States
What they do:
mRNA therapeutics to extend healthspan entering clinical trials
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HQ: San Francisco, CA, United States
What they do:
We are developing a drug to burn calories and increase metabolism…
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HQ: San Francisco, CA, United States
What they do:
Menten AI designs peptide and protein therapeutics using quantum…
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HQ: San Francisco, CA, United States
What they do:
Bioengineered kidneys for patients with kidney failure
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HQ: San Diego, CA, United States
What they do:
Targeting the Tumor Ecosystem to address cancer drug resistance.
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HQ: San Francisco, CA, United States
What they do:
Enabling Tissue Targeting of Therapies
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HQ: San Francisco, CA, United States
What they do:
High quality mRNA for therapeutic application
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HQ: San Diego, CA, United States
What they do:
Genetically engineering plants for disease resistance.
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HQ: San Francisco, CA, United States
What they do:
Genetically engineered viruses that teach your immune system to kill…
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HQ: San Francisco, CA, United States
What they do:
A Disease Focused Biotech, Building Multiple Billion Dollar Drugs
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HQ: San Francisco, CA, United States
What they do:
RWE Generation in minutes
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HQ: San Francisco, CA, United States
What they do:
The continuous oversight engine for clinical trials
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HQ: San Francisco, CA, United States
What they do:
Automating regulatory submissions for life sciences
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HQ: San Francisco, CA, United States
What they do:
The first Agentic platform for Oncology
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HQ: San Francisco, CA, United States
What they do:
Multimodal foundation models to predict uncollected patient biology
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HQ: San Francisco, CA, United States
What they do:
Control lab instruments with natural language.
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HQ: San Francisco, CA, United States
What they do:
The AI Workforce for Biopharma
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HQ: San Francisco, CA, United States
What they do:
We are a multi-strategy trading firm that trains AI traders.
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HQ: San Francisco, CA, United States
What they do:
Curing cancer. Starting with dogs.
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HQ: San Francisco, CA, United States
What they do:
Perlara: building the YC for rare disease parents
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HQ: San Francisco, CA, United States
What they do:
Redefining the Standard of Care for Iron Deficiency Anemia
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HQ: San Francisco, CA, United States
What they do:
Vaccines for any cancer or infection in weeks.
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HQ: San Francisco, CA, United States