What they do:
Group-Therapy Platform for Providers and Health Systems
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HQ: San Francisco, CA, United States
Top Digital Health Startups in the United States
This list has 336 startups and was last updated on Oct 15, 2026. 100 of them are hiring right now. Biggest hubs: San Francisco (190), New York (67), and Boston (13). Largest teams: Truepill, Clipboard, and Athelas. Latest round: Atmos Clinic raised $6M (Oct 8, 2026).
336 startupsPage 5 of 10
What they do:
Integrated, high touch healthcare — at scale
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HQ: New York, NY, United States
Delfino AI
Hiring
What they do:
Generative AI for administrative automation in healthcare
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HQ: San Francisco, CA, United States
What they do:
Enabling birth & postpartum doulas to easily accept insurance.
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HQ: New York, NY, United States
What they do:
Healthcare personal assistants for Medicare patients.
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HQ: New York, NY, United States
Layers
Hiring
What they do:
Improve your appearance by measuring, understanding, and tracking…
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HQ: San Francisco, CA, United States
Taiga
Hiring
What they do:
Autonomous medical billing
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HQ: San Francisco, CA, United States
Floracene
Hiring
What they do:
Vibecode + deploy HIPAA-compliant internal tools, no eng team needed
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HQ: New York, NY, United States
Hubble
Hiring
What they do:
AI-native retrieval engine for medical records
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HQ: Seattle, WA, United States
What they do:
Turn manual healthcare process into automated workflows
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HQ: Lehi, UT, United States
What they do:
At-home oral health testing, coaching & care
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HQ: San Francisco, CA, United States
What they do:
Scheduling software for digital health clinics to do more with less.
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HQ: San Francisco, CA, United States
What they do:
AI workforce management for healthcare
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HQ: San Francisco, CA, United States
What they do:
A research lab for one
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HQ: San Francisco, CA, United States
What they do:
The AI operating system for radiology networks
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HQ: San Francisco, CA, United States
What they do:
The lifestyle medicine layer for clinicians.
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HQ: San Francisco, CA, United States
Zen
Hiring
What they do:
Posture correction software
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HQ: New York, NY, United States
YC S21Early stage
What they do:
A white-label care enablement platform
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HQ: New York, NY, United States
What they do:
AI enabling digital urine diagnostics in the home
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HQ: Houston, TX, United States
What they do:
The #1 App to Quit Porn: Rebuild Focus and Intimacy
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HQ: Salt Lake City, UT, United States
What they do:
Entvin is building AI agents specifically designed to support regulatory teams in the life sciences industry. Our platform leverages AI to streamline…
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HQ: San Francisco, CA, United States
Knowtex
Hiring
What they do:
Making doctors 2x more efficient with AI note-taking & charge capture
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HQ: San Francisco, CA, United States
What they do:
Empowering every doctor and every patient to participate in research
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HQ: New York, NY, United States
What they do:
Unifying how the optical industry does business.
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HQ: Los Angeles, CA, United States
What they do:
At-cost preventive health: Labs, Scans, Genetics, Supplements and Rx
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HQ: San Francisco, CA, United States
What they do:
Helping hospitals identify and prevent avoidable harm using AI
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HQ: San Francisco, CA, United States
What they do:
coaching agents for athletes
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HQ: Boston, MA, United States
What they do:
AI agents for risk-bearing healthcare organizations
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HQ: San Francisco, CA, United States
What they do:
AI to run behavioral health programs better
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HQ: Chicago, IL, United States
What they do:
Adaptive training coach for runners, cyclists, and triathletes
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HQ: San Francisco, CA, United States
Plena Health
Hiring
What they do:
Plena is the AI operating system for specialty medical practices
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Full Stack Pharmaceutical Company for Personalized Peptides and GLP-1s
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HQ: San Francisco, CA, United States
What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
What they do:
Activating an overlooked force in medicine - the patient.
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HQ: San Francisco, CA, United States
What they do:
Intelligent Medical Record Reviews
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HQ: New York, NY, United States
What they do:
Personal doctors through chat
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HQ: New York, NY, United States