What they do:
Foundation models for planning orthopedic surgery
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HQ: San Francisco, CA, United States
Top Startups in California
This list has 3,698 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (3,173), Los Angeles (197), and San Diego (39). Largest teams: DoorDash, Stripe, and Airbnb. Latest round: Renue Life Sciences raised $250K (Oct 14, 2026).
3,698 startupsPage 45 of 103
What they do:
LLM context compression for better accuracy
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HQ: San Francisco, CA, United States
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Unified prediction markets trading platform
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HQ: San Francisco, CA, United States
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AI production engineer for regulated industries
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HQ: San Francisco, CA, United States
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Work with agents that already know you
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HQ: San Francisco, CA, United States
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AI Agents for Government Affairs
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HQ: San Francisco, CA, United States
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Frontier AI Defenses for Social Engineering Attacks
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HQ: San Francisco, CA, United States
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Evals, RL environments and training data for creative tasks
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HQ: San Francisco, CA, United States
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Intelligence for cultural institutions
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HQ: San Francisco, CA, United States
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Evals for humans
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HQ: San Francisco, CA, United States
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Your Capable Desktop AI Companion
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HQ: Irvine, CA, United States
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24/7 Personal Health & Longevity Companion
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HQ: San Francisco, CA, United States
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Autonomous operations for industrial distributors
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HQ: San Francisco, CA, United States
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Platform + FDEs that rebuild enterprises agent-first
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HQ: San Francisco, CA, United States
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Helping your company find 10x engineers.
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HQ: San Francisco, CA, United States
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AI Back-Office Automation for Commercial Lenders
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HQ: San Francisco, CA, United States
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Marketplace for AI agents to hire humans.
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HQ: San Francisco, CA, United States
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Building the Data Infrastructure layer for Physical AI.
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HQ: San Francisco, CA, United States
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Extrapolative AI to unlock First-in-Class drugs
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HQ: San Francisco, CA, United States
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AI nutrition coach in your pocket
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HQ: San Francisco, CA, United States
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The agentic OS for medical labs
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HQ: San Francisco, CA, United States
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AI-native CRO for clinical trial operations
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HQ: San Francisco, CA, United States
What they do:
Simulations of real people for market research
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HQ: San Francisco, CA, United States
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Patreon for AI Originals
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HQ: San Francisco, CA, United States
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AI-native pharma company
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HQ: San Francisco, CA, United States
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AI-Native FDA Regulatory Services
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HQ: San Francisco, CA, United States
What they do:
A personal or team assistant that works while you sleep
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HQ: San Francisco, CA, United States
What they do:
agents for the rest of us
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HQ: San Francisco, CA, United States
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We help lawyers start and scale AI-native law firms.
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HQ: San Francisco, CA, United States
What they do:
The AI-native contact center
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HQ: San Francisco, CA, United States
What they do:
Watch and create anime
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HQ: San Francisco, CA, United States
What they do:
The market behind AI hardware.
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HQ: San Francisco, CA, United States
What they do:
Building a neutral, sovereign alternative to Starlink
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HQ: San Francisco, CA, United States
What they do:
Making chemicals 100,000x faster
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HQ: San Francisco, CA, United States
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Reliable and safe data engineering and data science agents
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HQ: San Francisco, CA, United States
What they do:
Build everyday back-office agents on one live model of your books
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HQ: San Francisco, CA, United States