What they do:
Create custom NLP models
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HQ: Boston, MA, United States
Top Startups in Massachusetts
This list has 228 startups and was last updated on Oct 15, 2026. 15 of them are hiring right now. Biggest hubs: Boston (138), Cambridge (24), and Waltham (8). Largest teams: Ginkgo Bioworks, Modern Health, and Sendwave. Latest round: ArthroMeda raised $8.75M (Oct 13, 2026).
228 startupsPage 2 of 7
What they do:
Plaid for Commercial Real Estate
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HQ: Boston, MA, United States
What they do:
Making 'REAL' Cow and Human Milk!
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HQ: Boston, MA, United States
What they do:
High-precision, closed-loop neuromodulation devices
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HQ: Boston, MA, United States
What they do:
Gen-AI Designed Enzymes for Pharmaceutical Innovation
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HQ: Boston, MA, United States
What they do:
coaching agents for athletes
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HQ: Boston, MA, United States
What they do:
Simulate your customers with AI agents
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HQ: Boston, MA, United States
What they do:
Metal manufacturing, faster, cheaper, and more versatile.
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HQ: Boston, MA, United States
What they do:
Using DNA to store data.
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HQ: Boston, MA, United States
What they do:
An open-source operating system for reliable long-running agents
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HQ: Boston, MA, United States
What they do:
USA-made magnetics for robotics and defense.
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HQ: Boston, MA, United States
What they do:
A therapeutics platform for curing inflammatory disorders
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HQ: Boston, MA, United States
What they do:
Dendritic cell-based platform for cancer therapy
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HQ: Boston, MA, United States
What they do:
"If-then" conditional logic for protein drugs
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HQ: Boston, MA, United States
What they do:
Robotic Training Data at Scale
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HQ: Boston, MA, United States
What they do:
Scaling Genomic AI for Embryo Selection
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HQ: Boston, MA, United States
What they do:
Robots for the inspection and maintenance of data centers
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HQ: Boston, MA, United States
What they do:
Life sciences reagents and software
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HQ: Boston, MA, United States
What they do:
The AI-Native Consumer + Plaintiff Law Firm
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HQ: Boston, MA, United States
What they do:
Building Autonomous Research Agents for Trading
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HQ: Boston, MA, United States
What they do:
The fully autonomous intelligence layer in the sky.
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HQ: Boston, MA, United States
What they do:
The Intelligence layer for Drug Manufacturing
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HQ: Boston, MA, United States
What they do:
The IDE for Tokenmaxxers
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HQ: Boston, MA, United States
What they do:
Open source alternative to Semrush and Ahrefs
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HQ: Boston, MA, United States
What they do:
Sanitation and Health Rights in India (SHRI) fights alongside communities to end open defecation as a key step in an ongoing struggle for health equity and…
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HQ: Boston, MA, United States
What they do:
Infrastructure Cartography
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HQ: Boston, MA, United States
What they do:
Next-Generation Surgical Navigation and Robotics
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HQ: Boston, MA, United States
YC S19Early stage
What they do:
AI-controlled optical switching for AI clusters
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HQ: Boston, MA, United States
YC S26Early stage
What they do:
We make the most compact nuclear reactors
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HQ: Boston, MA, United States
YC X26Early stage
Sendwave
Acquired
What they do:
Instant, no fee international remittances.
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HQ: Boston, MA, United States
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HQ: Cambridge, MA, United States
Incorporated: 2023
Funding:
$189M · Equity · May 2026
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HQ: Boston, MA, United States
Incorporated: 2022
Funding:
$187M · Equity · May 2026
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HQ: Boston, MA, United States
Funding:
$180M · Equity · Apr 2026
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HQ: Boston, MA, United States
Incorporated: 2023
Funding:
$123M · Equity · Mar 2026
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HQ: Boston, MA, United States
Incorporated: 2026
Funding:
$121M · Equity · Mar 2026
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HQ: Wellesley Hills, MA, United States
Funding:
$110M · Equity · May 2026