
What they do:
Build full-stack applications for business operations with AI
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HQ: New York, NY, United States
This list has 233 startups and was last updated on Oct 15, 2026. 65 of them are hiring right now. Biggest hubs: San Francisco (137), New York (34), and Los Angeles (18). Largest teams: GrubMarket, Instacart, and Flexport. Latest round: Fleet Response Ultimate Parent raised $10M (Apr 10, 2026).

What they do:
Build full-stack applications for business operations with AI
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HQ: New York, NY, United States

What they do:
Multimodal foundation models to predict uncollected patient biology
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HQ: San Francisco, CA, United States

What they do:
AI teammates for logistics
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HQ: San Francisco, CA, United States

What they do:
Automating dexterous tasks in warehouses with AI-powered robots
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HQ: San Francisco, CA, United States

What they do:
FDE as a platform for rebuilding critical operations in software.
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HQ: San Francisco, CA, United States

What they do:
Building AI Native Customs Brokerages
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HQ: San Francisco, CA, United States

What they do:
The Intelligence layer for Drug Manufacturing
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HQ: Boston, MA, United States

What they do:
Making Defense Manufacturing Faster and Cheaper
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HQ: New York, NY, United States

What they do:
Drop-in robotic labor that works on Day 1
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HQ: Los Angeles, CA, United States

What they do:
AI-powered freight brokerage. Quote, book, and track loads in seconds.
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HQ: San Francisco, CA, United States

What they do:
AI-native freight brokerage
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HQ: San Francisco, CA, United States

What they do:
AI Operating System for Wholesale Distribution
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HQ: San Francisco, CA, United States

What they do:
Curing cancer. Starting with dogs.
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HQ: San Francisco, CA, United States

What they do:
AI Brokers for Industrial Trade
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HQ: San Francisco, CA, United States

What they do:
AI for the industries that power America.
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HQ: San Francisco, CA, United States

What they do:
Precision navigation for UAVs operating without GPS.
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HQ: San Francisco, CA, United States

What they do:
The AI decision engine for factories, warehouses and fleets
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HQ: San Francisco, CA, United States

What they do:
Lark - AI agents that automate workflows for wholesale distributors
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HQ: San Francisco, CA, United States

What they do:
Perlara: building the YC for rare disease parents
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HQ: San Francisco, CA, United States

What they do:
Multi-agent AI for physical logistics operations
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HQ: San Francisco, CA, United States

What they do:
Redefining the Standard of Care for Iron Deficiency Anemia
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HQ: San Francisco, CA, United States

What they do:
Turning messy inboxes into ERP-Ready Data
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HQ: San Francisco, CA, United States

What they do:
AI agents for global trade compliance
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HQ: San Francisco, CA, United States

What they do:
Vaccines for any cancer or infection in weeks.
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HQ: San Francisco, CA, United States

What they do:
Avion builds and operates autonomous eVTOL drones that deliver vital…
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HQ: San Francisco, CA, United States

What they do:
We help Fortune 500 companies hedge their supply chain risk
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HQ: San Francisco, CA, United States

What they do:
World Model for Freight
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HQ: New York, NY, United States
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HQ: Euless, TX, United States
Funding:
$10M · Apr 2026
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HQ: Pittsburgh, PA, United States
Funding:
$1.5M · Debt · Mar 2026

What they do:
Furniture rental for consumers and businesses.
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HQ: New York, NY, United States

What they do:
Autonomous VTOL delivery solutions.
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HQ: San Francisco, CA, United States

What they do:
Packaging for online brands.
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HQ: Los Angeles, CA, United States

What they do:
Uber for food.
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HQ: San Francisco, CA, United States
What they do:
Meals Delivered in 10 Minutes
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HQ: San Francisco, CA, United States

What they do:
Supervised Autonomous Heavy Equipment
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HQ: San Francisco, CA, United States

What they do:
Data and AI platform for Ecommerce & Cross-Border Logistics
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HQ: San Francisco, CA, United States