What they do:
Sandboxes for AI agents
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HQ: San Francisco, CA, United States
Top Infrastructure Startups
This list has 417 startups and was last updated on Oct 15, 2026. 111 of them are hiring right now. Biggest hubs: San Francisco (271), New York (38), and London (10). Largest teams: Fivetran, Firebase, and Heroku. Latest round: Supabase raised $150M (Oct 2, 2026).
417 startupsPage 8 of 12
What they do:
Independent AI evaluations lab
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HQ: New York, NY, United States
What they do:
Run open models as fast as your hardware allows
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HQ: San Francisco, CA, United States
What they do:
The continuous oversight engine for clinical trials
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HQ: San Francisco, CA, United States
What they do:
Building intellectually curious AI
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HQ: San Francisco, CA, United States
What they do:
Everything on anyone.
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Platform Engineering
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HQ: San Francisco, CA, United States
What they do:
Self-tuning search for products and files
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HQ: San Francisco, CA, United States
What they do:
Infra to build your own software factory
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HQ: New York, NY, United States
What they do:
RL environments for robotics companies
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What they do:
AI SRE agent that triages, coordinates, and fixes production incidents
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HQ: San Francisco, CA, United States
What they do:
Your software should build itself.
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What they do:
API sandboxes, built for AI agents
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HQ: San Francisco, CA, United States
What they do:
Compression middleware that improves LLM outputs
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HQ: San Francisco, CA, United States
What they do:
Payments for Conversational Agents
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HQ: San Francisco, CA, United States
What they do:
staffing firms with dreach grow revenue faster.
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HQ: San Francisco, CA, United States
What they do:
Distributed runtime for AI workloads at scale
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HQ: San Francisco, CA, United States
What they do:
The control point for AI agents at work.
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HQ: San Francisco, CA, United States
What they do:
The IDE for Tokenmaxxers
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HQ: Boston, MA, United States
What they do:
Co-designing the fastest intelligence
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HQ: San Francisco, CA, United States
What they do:
Self-optimizing neocloud that cuts LLM costs by 100x
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HQ: San Francisco, CA, United States
What they do:
Market for future inference capacity
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HQ: San Francisco, CA, United States
What they do:
Expert computer-use data for frontier AI labs
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What they do:
Training company-specific models that approve AI actions.
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HQ: San Francisco, CA, United States
What they do:
Autonomous rovers to make the ‘Google Maps’ of underground utilities
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HQ: San Francisco, CA, United States
What they do:
Open source AI gateway that turns your traffic into better models
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HQ: San Francisco, CA, United States
What they do:
Intelligent Cloud for AI workloads
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HQ: San Francisco, CA, United States
What they do:
Building in-house, frontier AI labs for companies
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HQ: San Francisco, CA, United States
What they do:
Fast inference for voice
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HQ: San Francisco, CA, United States
What they do:
Turn any website into an MCP for your agents, in minutes
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HQ: San Francisco, CA, United States
What they do:
reducing agent reasoning into a graph search problem
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HQ: San Francisco, CA, United States
What they do:
Agent swarms that make long-running tasks exponentially faster
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HQ: London, United Kingdom
What they do:
Durable state for AI agents
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HQ: New York, NY, United States
What they do:
Verify that the expected person is in control before key actions.
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What they do:
Make your LLMs 3x faster.
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HQ: San Francisco, CA, United States
What they do:
Turning messy inboxes into ERP-Ready Data
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HQ: San Francisco, CA, United States