Metriport
Hiring
What they do:
Healthcare data infrastructure for next generation care delivery.
Quick facts:
HQ: San Francisco, CA, United States
Top AI Startups in California
This list has 1,434 startups and was last updated on Oct 16, 2026. 461 of them are hiring right now. Biggest hubs: San Francisco (1,360), Los Angeles (47), and San Diego (4). Largest teams: Cruise, Relativity Space, and Athelas. Latest round: Agriculture Scout AI raised $425K (Oct 13, 2026).
1,434 startupsPage 4 of 40
What they do:
AI that finds the right buyers and books sales meetings
Quick facts:
HQ: San Francisco, CA, United States
Synthio Labs
Hiring
What they do:
Agentic AI platform for Pharma GTM teams
Quick facts:
HQ: San Francisco, CA, United States
Two Dots
Hiring
What they do:
AI fraud prevention and underwriting agent
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Real-World Data for Health Innovation
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HQ: San Francisco, CA, United States
Uplane
Hiring
What they do:
Replace marketing agencies with AI
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HQ: San Francisco, CA, United States
What they do:
AI Super-Apps to Live Easier | The anything anytime superapps…
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HQ: Los Angeles, CA, United States
What they do:
Empowering women. Period.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
A new kind of power for finance teams
Quick facts:
HQ: San Francisco, CA, United States
Atomic
Hiring
What they do:
API that lets companies embed investment accounts into their services
Quick facts:
HQ: San Francisco, CA, United States
Mach9
Hiring
What they do:
AI CAD Software for Civil Engineering
Quick facts:
HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
Quick facts:
HQ: San Francisco, CA, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
Quick facts:
HQ: San Francisco, CA, United States
Omnistrate
Hiring
What they do:
Build your control plane to deploy your product in your customer VPC…
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HQ: San Francisco, CA, United States
mdhub
Hiring
What they do:
AI-native operating system for behavioral health clinics.
Quick facts:
HQ: San Francisco, CA, United States
Ember
Hiring
What they do:
AI RCM. Increase net revenue by 16%.
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HQ: San Francisco, CA, United States
Harper
Hiring
What they do:
AI-native commercial insurance brokerage
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HQ: San Francisco, CA, United States
What they do:
The Javascript framework for building AI agents, from the Gatsby devs
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HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
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HQ: San Francisco, CA, United States
What they do:
Handl converts documents (invoices, income stabs, custom forms, etc.)…
Quick facts:
HQ: San Francisco, CA, United States
HUD
Hiring
What they do:
Platform and marketplace for RL environments and AI data
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Replika is an AI friend that you can talk to designed to make you…
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HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
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HQ: San Francisco, CA, United States
Respan
Hiring
What they do:
Self-driving observability, evals, and gateway for AI agents
Quick facts:
HQ: San Francisco, CA, United States
Datrics
Hiring
What they do:
Generative AI Healthcare Coding Automation
Quick facts:
HQ: San Francisco, CA, United States
Entangl
Hiring
What they do:
Find & resolve issues in data center engineering & operations using AI
Quick facts:
HQ: San Francisco, CA, United States
Strada
Hiring
What they do:
AI agents that run insurance operations
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HQ: San Francisco, CA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
Serif Health
Hiring
What they do:
Healthcare Price Transparency APIs and Data Products
Quick facts:
HQ: Los Angeles, CA, United States
Replo
Hiring
What they do:
Sell anything
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HQ: San Francisco, CA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
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HQ: San Francisco, CA, United States
OneSchema
Hiring
What they do:
The AI Cowork for big data
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HQ: San Francisco, CA, United States
What they do:
We make Orca, MIT open source terminal-based agent orchestrator
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HQ: San Francisco, CA, United States
Gym Class
Hiring
What they do:
Connecting the world by simulating it
Quick facts:
HQ: San Francisco, CA, United States
loopfour
Hiring
What they do:
Workflow automation, without AI hallucinations.
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HQ: San Francisco, CA, United States
LiteLLM
Hiring
What they do:
Call every LLM API like it's OpenAI [100+ LLMs]
Quick facts:
HQ: San Francisco, CA, United States