Top AI Startups in San Francisco

2 employeesYC F24Early stage

Applied AI & ML Developer tools

HumanLayer

Hiring

What they do:

The multiplayer control plane for your software factory

Quick facts:

2 employeesYC F24Early stage

Paragon

Hiring

What they do:

The AI Growth Engine for Industrials

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2 employeesYC W25Early stage

Applied AI & ML Productivity & automation

Thirdlayer

Hiring

What they do:

Continual learning for enterprise AI

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2 employeesYC W25Early stage

Applied AI & ML Banking & lending Real estate & construction

Chestnut

Hiring

What they do:

The first AI mortgage lender

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2 employeesYC X25Early stage

Theta

What they do:

Specialized AI for Every Job

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7 employeesYC X25Early stage

MangoDesk

Hiring

What they do:

Long-horizon RL environments

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2 employeesYC S25Early stage2 open roles

AI agents & assistants Applied AI & ML Developer tools

Humwork

Hiring

What they do:

Human experts as API for AI Agents

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2 employeesYC X26Early stage

AI agents & assistants Applied AI & ML

Wedge

Hiring

What they do:

AI Employees for Healthcare

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2 employeesYC S25Early stage

Robotics & drones Applied AI & ML Manufacturing & chips

OS3

Hiring

What they do:

Affordable, intelligent humanoid robots built to deploy at scale

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2 employeesYC S26Early stage

Applied AI & ML Accounting & finance ops

Alder

Hiring

What they do:

AI employees for finance, starting with accounts receivable.

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2 employeesYC F25Early stage

Applied AI & ML Developer tools Cloud & infrastructure

Unsiloed AI

Hiring

What they do:

API for parsing multimodal unstructured data

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2 employeesYC F25Early stage

Cloud & infrastructure Applied AI & ML Data & analytics Developer tools

Lemma

Hiring

What they do:

Production Monitoring for AI agents

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2 employeesYC F25Early stage

Wellness & mental health Applied AI & ML Digital health & care E-commerce & retail

Layers

Hiring

What they do:

Improve your appearance by measuring, understanding, and tracking…

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2 employeesYC F25Early stage

Robotics & drones Applied AI & ML Developer tools Productivity & automation

Waddle Labs

Hiring

What they do:

LLMs that control robots

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2 employeesYC S26Early stage

Payna

Hiring

What they do:

AI Licensing Agent for Regulated Industries

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2 employeesYC W26Early stage

Avoice

What they do:

AI-native workspace for AEC

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7 employeesYC W26Early stage

Developer tools Cloud & infrastructure Applied AI & ML

Salus

Hiring

What they do:

Guardrails to validate your agent's actions before they execute

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2 employeesYC W26Early stage

AI agents & assistants Applied AI & ML HR & recruiting Manufacturing & chips

Ventura

Hiring

What they do:

AI Workforce for Distributors and Manufacturers

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2 employeesYC W26Early stage

Applied AI & ML Banking & lending

Fenrock AI

Hiring

What they do:

AI agents for banks

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2 employeesYC W26Early stage

Chasi

Hiring

What they do:

AI Revenue Engine for the Equipment Industry

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2 employeesYC W26Early stage

HR & recruiting Applied AI & ML Marketplaces

Tsenta

Hiring

What they do:

AI career agent that finds matching jobs & applies on your behalf

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2 employeesYC S26Early stage1 open roles

Insurance Applied AI & ML

Hedge

Hiring

What they do:

AI-Native insurance company

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2 employeesYC X26Early stage16 open roles

Applied AI & ML Manufacturing & chips

Discovered Materials

Hiring

What they do:

AI scientists to discover materials for the semiconductor industry.

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2 employeesYC X26Early stage

Payments Applied AI & ML Cloud & infrastructure

Uno Wallet

Hiring

What they do:

The AI mobile wallet that replaces Apple Pay

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2 employeesYC X26Early stage

flowscope

Hiring

What they do:

AI implementation firm that maps and automates business processes

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2 employeesYC X26Early stage

Applied AI & ML Cloud & infrastructure

Parasma

Hiring

What they do:

Replacing GPUs with human brain cells

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2 employeesYC S26Early stage

Applied AI & ML Accounting & finance ops

Rex

Hiring

What they do:

AI-native BPO for enterprise order-to-cash

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2 employeesYC S26Early stage

Robotics & drones Applied AI & ML Space, aviation & defense

IMPACT Drones

Hiring

What they do:

Air Defense as a Service for Civilian Infrastructure.

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2 employeesYC S26Early stage

Applied AI & ML Productivity & automation

screenpipe

Hiring

What they do:

Turn your company's computer work into AI agents.

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2 employeesYC S26Early stage

Callbook AI

What they do:

AI collections agency for late stage portfolios

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7 employeesYC S26Early stageRemote

Rational

Hiring

What they do:

First Zero-human Accounting Firm

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2 employeesYC S26Early stage

Applied AI & ML Cloud & infrastructure Climate & energy

Edviro

Hiring

What they do:

AI That Operates Energy Infrastructure

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2 employeesYC S26Early stage

Applied AI & ML Developer tools Cloud & infrastructure

Workers IO

Hiring

What they do:

Simulation Environments for Verifying Mission Critical Software

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2 employeesYC F26Early stage

Insurance AI agents & assistants AI infrastructure & models Applied AI & ML

Covera

Hiring

What they do:

AI-native OS for insurance brokers

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2 employeesYC F26Early stage

Applied AI & ML Accounting & finance ops

Finlens

What they do:

AI Accounting for Founders & Accountants

Quick facts:

6 employeesYC W20Early stage