What they do:
AI for product formulation
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HQ: San Francisco, CA, United States
Top B2B Software Startups in California
This list has 2,349 startups and was last updated on Oct 15, 2026. 592 of them are hiring right now. Biggest hubs: San Francisco (2,110), Los Angeles (79), and San Diego (12). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,349 startupsPage 21 of 66
What they do:
Restaurant Loyalty Using Quiz
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HQ: San Francisco, CA, United States
What they do:
Build AI influencers that autonomously create content, engage fans…
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HQ: San Francisco, CA, United States
Bunting Labs
Hiring
What they do:
AI Models for GIS
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HQ: San Francisco, CA, United States
What they do:
Founder-level assistance whenever customers need it, at scale
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HQ: San Francisco, CA, United States
What they do:
Accelerate clinical trials with real-time, actionable insights
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HQ: San Francisco, CA, United States
Finta
Hiring
What they do:
Magically simplify accounting and taxes
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HQ: San Francisco, CA, United States
What they do:
Manage a swarm of AI agents to get real work done
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HQ: San Francisco, CA, United States
What they do:
Give Your Employee An Employee
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HQ: San Francisco, CA, United States
Deep24
Hiring
What they do:
AI coach for your entire life
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HQ: San Francisco, CA, United States
What they do:
AI Supply Chain Manager for CPG
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HQ: San Francisco, CA, United States
What they do:
The user infrastructure platform
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HQ: San Francisco, CA, United States
What they do:
An AI physics simulator for AI chip design
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HQ: San Francisco, CA, United States
Substrate
Hiring
What they do:
Artificial Intelligence for your medical billing team
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HQ: San Francisco, CA, United States
Mage Legal
Hiring
What they do:
Automatic AI Legal Diligence
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HQ: San Francisco, CA, United States
Zettascale Computing
Hiring
What they do:
Chips for frontier AI
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HQ: San Francisco, CA, United States
Cerulion
Hiring
What they do:
Open source operating system for robots
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HQ: San Francisco, CA, United States
Sonatoria
Hiring
What they do:
Helping Startups Grow Organically
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HQ: Los Angeles, CA, United States
What they do:
Collaborative workspace for patent litigators
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HQ: San Francisco, CA, United States
What they do:
The Localization Engineering Platform
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HQ: San Francisco, CA, United States
HumanLayer
Hiring
What they do:
The multiplayer control plane for your software factory
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HQ: San Francisco, CA, United States
Paragon
Hiring
What they do:
The AI Growth Engine for Industrials
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HQ: San Francisco, CA, United States
Thirdlayer
Hiring
What they do:
Continual learning for enterprise AI
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HQ: San Francisco, CA, United States
What they do:
Specialized AI for Every Job
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HQ: San Francisco, CA, United States
MangoDesk
Hiring
What they do:
Long-horizon RL environments
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HQ: San Francisco, CA, United States
What they do:
Create Whiteboard Explainer Videos with AI from a Prompt or Document
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HQ: Stockton, CA, United States
Orange Slice
Hiring
What they do:
Agentic sales enrichment spreadsheet
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HQ: San Francisco, CA, United States
Humwork
Hiring
What they do:
Human experts as API for AI Agents
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HQ: San Francisco, CA, United States
Kalinda
Hiring
What they do:
Deep research for class action law firms
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HQ: San Francisco, CA, United States
OS3
Hiring
What they do:
Affordable, intelligent humanoid robots built to deploy at scale
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HQ: San Francisco, CA, United States
Alder
Hiring
What they do:
AI employees for finance, starting with accounts receivable.
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HQ: San Francisco, CA, United States
Unsiloed AI
Hiring
What they do:
API for parsing multimodal unstructured data
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HQ: San Francisco, CA, United States
What they do:
Robotic factories that build robots
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HQ: Emeryville, CA, United States
Lemma
Hiring
What they do:
Production Monitoring for AI agents
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HQ: San Francisco, CA, United States
Waddle Labs
Hiring
What they do:
LLMs that control robots
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HQ: San Francisco, CA, United States
Payna
Hiring
What they do:
AI Licensing Agent for Regulated Industries
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HQ: San Francisco, CA, United States