What they do:
The E2E testing layer for AI-driven development
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HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 24 of 59
What they do:
Agents that learn your company and work 24/7
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HQ: San Francisco, CA, United States
Proliferate
Hiring
What they do:
Do your life's work with agents
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HQ: San Francisco, CA, United States
YC S25Early stage
Relling
Hiring
What they do:
deploying the first billion robots for manufacturing
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI agents for E2E testing across mobile & web
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HQ: San Francisco, CA, United States
What they do:
Airline customer service, fully automated.
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HQ: San Francisco, CA, United States
What they do:
The GD&T Analysis Platform for Engineering Drawings
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HQ: San Francisco, CA, United States
What they do:
Browser infra for AI agents: sessions, auth, proxies, payments
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HQ: San Francisco, CA, United States
Juxta
Hiring
What they do:
Building a GPS alternative 100x more powerful with no hardware needed.
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HQ: San Francisco, CA, United States
YC S25Early stage
What they do:
AI that creates and runs ads, end-end
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HQ: San Francisco, CA, United States
Soren
Hiring
What they do:
The AI Transformation Company
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HQ: San Francisco, CA, United States
YC F25Early stage
What they do:
API for unlimited, durable, real-time streams
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HQ: San Francisco, CA, United States
What they do:
AI Infra for real-time vision applications
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HQ: San Francisco, CA, United States
VOYGR
Hiring
What they do:
Real-world place intelligence for AI apps and agents
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HQ: San Francisco, CA, United States
YC W26Early stage
Cardinal
Hiring
What they do:
Revenue Agents for GTM teams
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HQ: San Francisco, CA, United States
YC W26Early stage
What they do:
Agents that run short-term rental operations end-to-end
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HQ: San Francisco, CA, United States
What they do:
Real-world sandboxes to test and train AI agents
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HQ: San Francisco, CA, United States
AgentPhone
Hiring
What they do:
Phone Numbers for AI Agents
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HQ: San Francisco, CA, United States
YC X26Early stage
What they do:
Find and engage with desperate buyers across LinkedIn, Email, and X
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HQ: San Francisco, CA, United States
What they do:
Scale AI scientists whose own breakthroughs accelerate the next.
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HQ: San Francisco, CA, United States
What they do:
Automated LiveOps for Game Studios
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HQ: San Francisco, CA, United States
What they do:
Autonomous Customer Operations
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HQ: San Francisco, CA, United States
What they do:
The AI-native trading company: factory prices, delivered, one number
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HQ: San Francisco, CA, United States
What they do:
The AI BPO for financial servies, run by computer-use agents
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HQ: San Francisco, CA, United States
What they do:
Earned intelligence for every company
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HQ: San Francisco, CA, United States
What they do:
AI that finds value creation opportunities across enterprise…
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HQ: San Francisco, CA, United States
Operon
Hiring
What they do:
Agentic data layer for manufacturing & process industries.
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HQ: San Francisco, CA, United States
YC S26Early stage
Lamb Labs
Hiring
What they do:
Lightning fast chips with hardcoded AI models
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HQ: San Francisco, CA, United States
YC S26Early stage
What they do:
Grok bot for GTM & Revenue teams
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HQ: San Francisco, CA, United States
What they do:
Context layer for enterprise AI surveying employees with voice agents
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HQ: San Francisco, CA, United States
What they do:
We tell sellers exactly when a company is ready to buy.
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HQ: San Francisco, CA, United States
Spine
Hiring
What they do:
We run benefits, payroll & compliance for startups, for free
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HQ: San Francisco, CA, United States
YC F26Early stage
What they do:
A live watermark inside AI voice that survives phone calls
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HQ: San Francisco, CA, United States
What they do:
One-click screen sharing with installation-free viewing on all devices
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HQ: San Francisco, CA, United States
What they do:
AI-Native Restaurant POS
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HQ: San Francisco, CA, United States
What they do:
Sell beyond the store.
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HQ: San Francisco, CA, United States