What they do:
Mobile app and coaching program that helps employees sleep better
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HQ: San Francisco, CA, United States
Top B2B Software Startups in San Francisco
This list has 2,110 startups and was last updated on Oct 15, 2026. 572 of them are hiring right now. Largest teams: Stripe, Deel, and GrubMarket. Latest round: Modal raised $750M (Oct 14, 2026).
2,110 startupsPage 25 of 59
What they do:
2 sided Marketplace for accelerating medical research
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HQ: San Francisco, CA, United States
What they do:
We make it simple for call centers to automate quality assurance.
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HQ: San Francisco, CA, United States
What they do:
AI agents rewriting & optimising your internal documentation for LLMs
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HQ: San Francisco, CA, United States
What they do:
Get your brand discovered and recommended by ChatGPT
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HQ: San Francisco, CA, United States
What they do:
Superpowers for litigators
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HQ: San Francisco, CA, United States
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AI-powered product assistance for modern software teams
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HQ: San Francisco, CA, United States
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Frontier AI to stop fraud, abuse, and financial crimes.
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HQ: San Francisco, CA, United States
What they do:
Headcount & Compensation Management
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HQ: San Francisco, CA, United States
What they do:
Automating Data Entry for Clinical Trials
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HQ: San Francisco, CA, United States
What they do:
Revenue Superintelligence
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HQ: San Francisco, CA, United States
What they do:
A marketplace for B2B businesses to buy warm intros.
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HQ: San Francisco, CA, United States
What they do:
QA agents that write tests 10x faster with zero maintenance
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HQ: San Francisco, CA, United States
What they do:
Invoicing that pays you even if your buyer doesn’t
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HQ: San Francisco, CA, United States
What they do:
We build floating solar data centers
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HQ: San Francisco, CA, United States
What they do:
Executable healthcare contracts
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HQ: San Francisco, CA, United States
What they do:
AI Employees for Distributors
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HQ: San Francisco, CA, United States
What they do:
The Open Source Agentic Browser
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HQ: San Francisco, CA, United States
What they do:
Reliable AI for Regulated Ops
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HQ: San Francisco, CA, United States
What they do:
AI Affiliate Network For Financial Companies
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HQ: San Francisco, CA, United States
What they do:
AI tutor starting with maths and science
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HQ: San Francisco, CA, United States
What they do:
Cooking something sweet and salty!
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HQ: San Francisco, CA, United States
What they do:
Connect with hotel owners around the world.
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HQ: San Francisco, CA, United States
What they do:
Deep intelligence for private markets
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HQ: San Francisco, CA, United States
What they do:
The authentication framework for TypeScript
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HQ: San Francisco, CA, United States
What they do:
Product Native Models
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HQ: San Francisco, CA, United States
What they do:
Streamlining Data Capture to Report Creation for Heavy Industries
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HQ: San Francisco, CA, United States
What they do:
Real-world company data for frontier AI
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HQ: San Francisco, CA, United States
What they do:
We sell GPUs.
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HQ: San Francisco, CA, United States
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The Open-Source Alternative to Claude Managed Agents
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HQ: San Francisco, CA, United States
What they do:
Build an API to interact with any website.
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HQ: San Francisco, CA, United States
What they do:
Training Data for Recursive Self-Improvement
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HQ: San Francisco, CA, United States
What they do:
AI native real-estate appraisal firm
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HQ: San Francisco, CA, United States
What they do:
The full-stack AI financial audit firm
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HQ: San Francisco, CA, United States
What they do:
Operational Intelligence for Global Logistics
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HQ: San Francisco, CA, United States
What they do:
The AI sales agent for CPG brands
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HQ: San Francisco, CA, United States