What they do:
The Most-Loved IT Documentation Platform
Quick facts:
HQ: Fort Collins, CO, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 12 of 108
IOMETE
Hiring
What they do:
Self-hosted data lakehouse platform
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HQ: San Francisco, CA, United States
What they do:
The AI Support Agent for Ecommerce
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HQ: Boston, MA, United States
Strada
Hiring
What they do:
AI agents that run insurance operations
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HQ: San Francisco, CA, United States
What they do:
A platform to plan, book and manage global and group travel.
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HQ: Boulder, CO, United States
Castle
Hiring
What they do:
Block bots & bad behavior
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HQ: San Francisco, CA, United States
What they do:
Just-in-time training and communication for frontline healthcare teams
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HQ: San Francisco, CA, United States
Nestor
Hiring
What they do:
Skills-based talent management solutions for a dynamic workforce.
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HQ: San Francisco, CA, United States
Mutiny
Hiring
What they do:
Your AI agent for creating anything customer-facing, in minutes.
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HQ: New York, NY, United States
Accord
Hiring
What they do:
The Revenue Excellence Platform
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HQ: San Francisco, CA, United States
Handoff
Hiring
What they do:
AI estimator & agent for remodelers.
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HQ: Austin, TX, United States
Swif.ai
Hiring
What they do:
Manage every device. Govern every AI agent.
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HQ: San Francisco, CA, United States
Runway
Hiring
What they do:
Easier and more reliable mobile app releases for teams.
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HQ: New York, NY, United States
What they do:
Design and collaborate in multiple dimensions.
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HQ: Reston, VA, United States
What they do:
Subscription infrastructure & paywall experimentation for mobile apps
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HQ: New York, NY, United States
Serif Health
Hiring
What they do:
Healthcare Price Transparency APIs and Data Products
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HQ: Los Angeles, CA, United States
Replo
Hiring
What they do:
Sell anything
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HQ: San Francisco, CA, United States
OneSchema
Hiring
What they do:
The AI Cowork for big data
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HQ: San Francisco, CA, United States
What they do:
We make Orca, MIT open source terminal-based agent orchestrator
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HQ: San Francisco, CA, United States
What they do:
The real-time retrieval engine for search, feeds, and agents.
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HQ: New York, NY, United States
Medplum
Hiring
What they do:
API first electronic health record (EHR) that is open source
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HQ: San Francisco, CA, United States
Axle
Hiring
What they do:
AI-native clearinghouse for insurance
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HQ: New York, NY, United States
loopfour
Hiring
What they do:
Workflow automation, without AI hallucinations.
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HQ: San Francisco, CA, United States
What they do:
Production-ready document processing
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HQ: New York, NY, United States
Vector
Hiring
What they do:
Advertising for the new internet
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HQ: Boston, MA, United States
LiteLLM
Hiring
What they do:
Call every LLM API like it's OpenAI [100+ LLMs]
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HQ: San Francisco, CA, United States
Artie
Hiring
What they do:
Software that streams data from databases to warehouses in real-time
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HQ: San Francisco, CA, United States
Readily
Hiring
What they do:
AI Compliance Platform for Healthcare Organizations
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HQ: San Francisco, CA, United States
FleetWorks
Hiring
What they do:
AI enabled marketplace matching trucks with jobs
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HQ: San Francisco, CA, United States
Tamarind Bio
Hiring
What they do:
AI Inference Platform for Drug Discovery
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HQ: San Francisco, CA, United States
What they do:
Frontier coding data for training and evaluating LLMs
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HQ: San Francisco, CA, United States
Arva AI
Hiring
What they do:
AI for critical banking operations
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HQ: New York, NY, United States
Contrario
Hiring
What they do:
AI hiring platform powered by expert recruiters
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HQ: San Francisco, CA, United States
Volantio
Hiring
What they do:
Post-booking revenue and capacity optimization for airlines…
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HQ: Atlanta, GA, United States
What they do:
Embedded Analytics and Data Sharing Platform
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HQ: New York, NY, United States
What they do:
The easiest way to set up a modern data stack
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HQ: San Francisco, CA, United States