What they do:
2 sided Marketplace for accelerating medical research
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HQ: San Francisco, CA, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 38 of 108
What they do:
Help business find and discover AI solutions
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HQ: Seattle, WA, United States
What they do:
Classify Anything
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HQ: CA, United States
What they do:
Serverless Infrastructure Platform for AI
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HQ: New York, NY, United States
What they do:
We make it simple for call centers to automate quality assurance.
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HQ: San Francisco, CA, United States
What they do:
AI agents rewriting & optimising your internal documentation for LLMs
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HQ: San Francisco, CA, United States
What they do:
Get your brand discovered and recommended by ChatGPT
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HQ: San Francisco, CA, United States
What they do:
Internal developer platform for Terraform, OpenTofu and Helm
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HQ: Los Angeles, CA, United States
What they do:
Claude Code design workspace built for product teams
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HQ: Issaquah, WA, United States
What they do:
Building the definitive all-in-one on-device AI productivity tool
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HQ: Los Angeles, CA, United States
What they do:
Superpowers for litigators
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HQ: San Francisco, CA, United States
What they do:
Palantir for Web3
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HQ: New York, NY, United States
What they do:
AI-powered product assistance for modern software teams
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HQ: San Francisco, CA, United States
What they do:
Dataset Management for AI Trainers
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HQ: New York, NY, United States
What they do:
Build and host internal tools
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HQ: Ashburn, VA, United States
What they do:
Frontier AI to stop fraud, abuse, and financial crimes.
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HQ: San Francisco, CA, United States
What they do:
AI contract repository
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HQ: New York, NY, United States
What they do:
Headcount & Compensation Management
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HQ: San Francisco, CA, United States
What they do:
Automating Data Entry for Clinical Trials
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HQ: San Francisco, CA, United States
What they do:
Shopify for Homebuilders
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HQ: Boulder, CO, United States
What they do:
An all-in-one platform for building internal agents & workflows
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HQ: Salt Lake City, UT, United States
What they do:
AI Assistant for Excel
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HQ: New York, NY, United States
What they do:
The Modern Surety Bond Platform
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HQ: Austin, TX, United States
What they do:
Revenue Superintelligence
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HQ: San Francisco, CA, United States
What they do:
A marketplace for B2B businesses to buy warm intros.
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HQ: San Francisco, CA, United States
What they do:
QA agents that write tests 10x faster with zero maintenance
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HQ: San Francisco, CA, United States
What they do:
Invoicing that pays you even if your buyer doesn’t
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HQ: San Francisco, CA, United States
What they do:
We build floating solar data centers
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HQ: San Francisco, CA, United States
What they do:
Executable healthcare contracts
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HQ: San Francisco, CA, United States
What they do:
Navigate any set of data - no matter how large - in minutes.
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HQ: New York, NY, United States
What they do:
AI Employees for Distributors
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HQ: San Francisco, CA, United States
What they do:
The Open Source Agentic Browser
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HQ: San Francisco, CA, United States
What they do:
Reliable AI for Regulated Ops
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HQ: San Francisco, CA, United States
What they do:
AI Affiliate Network For Financial Companies
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HQ: San Francisco, CA, United States
What they do:
The living map of your organization
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HQ: New York, NY, United States
What they do:
Bookkeeping, compliance and tax for founders
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HQ: New York, NY, United States