What they do:
Java-native multi-agentic AI operating system for enterprise
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HQ: New York, NY, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 42 of 108
What they do:
Agents for quantitative research and financial data science.
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HQ: San Francisco, CA, United States
What they do:
Datadog for industrial robots
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HQ: San Francisco, CA, United States
What they do:
Legal Agent that delivers finished work
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HQ: San Francisco, CA, United States
What they do:
AI teammate for finance and operations teams at consumer brands
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HQ: New York, NY, United States
What they do:
The AI infrastructure for cash-flow-aligned business rent
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HQ: Miami, FL, United States
What they do:
Automating workflows.
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HQ: San Francisco, CA, United States
What they do:
Technology for cities to automate and manage their traffic lights.
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HQ: Dallas, TX, United States
What they do:
Turn employees' AI skills into shared company infrastructure
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Lending Operations
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HQ: San Francisco, CA, United States
What they do:
The reliability platform for last-mile delivery
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HQ: New York, NY, United States
What they do:
The Lovable & Replit killers
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HQ: San Francisco, CA, United States
What they do:
Stripe for telephony
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HQ: Lehi, UT, United States
What they do:
Struct keeps prod running
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HQ: San Francisco, CA, United States
What they do:
The AI Assistant for Gmail
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HQ: San Francisco, CA, United States
What they do:
AI powered debugging notebooks for incident response
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HQ: San Francisco, CA, United States
What they do:
Building AI systems that improve from experience.
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HQ: San Francisco, CA, United States
What they do:
Hire amazing engineers by seeing how they use AI
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HQ: San Francisco, CA, United States
What they do:
A foundation model for physics.
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HQ: San Francisco, CA, United States
What they do:
Fast and Data-Driven Immigration Platform
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HQ: San Francisco, CA, United States
What they do:
Protect and Grow Long-tail Revenue
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HQ: San Francisco, CA, United States
What they do:
Test, monitor, and improve your voice agents
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HQ: San Francisco, CA, United States
What they do:
Continual Learning for Agents
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HQ: San Francisco, CA, United States
What they do:
Open Source React.js Library for AI Chat
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HQ: San Francisco, CA, United States
What they do:
Custom models trained on your data
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HQ: San Francisco, CA, United States
What they do:
Creator marketing that scales like paid ads
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HQ: San Francisco, CA, United States
What they do:
We automate your entire product development lifecycle.
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HQ: San Francisco, CA, United States
What they do:
Open-source frontier models for knowledge work
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HQ: San Francisco, CA, United States
What they do:
AI-native financial institution for global businesses + agents.
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HQ: New York, NY, United States
What they do:
Understand your users beyond the numbers
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HQ: San Francisco, CA, United States
What they do:
A personal EA in your iMessage
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HQ: San Francisco, CA, United States
What they do:
Specialized AI for Critical Industries
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HQ: San Francisco, CA, United States
What they do:
Automatically write and update internal docs with every code commit.
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HQ: San Francisco, CA, United States
What they do:
Self-Driving CI: fast AI-native GitHub Actions runners
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HQ: San Francisco, CA, United States
What they do:
Build and ship native Swift apps with AI
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HQ: San Francisco, CA, United States
What they do:
Cursor for Email
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HQ: San Francisco, CA, United States