What they do:
Building medical school for AI Agents
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HQ: San Francisco, CA, United States
Top B2B Software Startups in the United States
This list has 3,865 startups and was last updated on Oct 15, 2026. 827 of them are hiring right now. Biggest hubs: San Francisco (2,110), New York (555), and Los Angeles (79). Largest teams: Stripe, Deel, and GrubMarket. Latest round: Onebrief raised $151M (Oct 14, 2026).
3,865 startupsPage 43 of 108
What they do:
AI content manager that grows your company's online presence
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HQ: San Francisco, CA, United States
What they do:
AI infrastructure for biosecurity
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HQ: New York, NY, United States
What they do:
Truckload Planning at Machine Precision
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HQ: San Francisco, CA, United States
What they do:
AI-native software for managing rail and bulk operations.
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HQ: Olathe, KS, United States
What they do:
AI employees trained on your firm's workflows.
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HQ: San Francisco, CA, United States
What they do:
Production infrastructure on autopilot
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HQ: San Francisco, CA, United States
What they do:
Digital transformation for real economy businesses
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HQ: San Francisco, CA, United States
What they do:
Studio-Grade Design at Scale
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HQ: San Francisco, CA, United States
What they do:
Continuous AI pentesting that finds and fixes vulnerabilities
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HQ: San Francisco, CA, United States
What they do:
AI clerks that automate your payables
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HQ: San Francisco, CA, United States
What they do:
Expressive conversational AI
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HQ: San Francisco, CA, United States
What they do:
Protect, monitor and defend your Internet presence
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HQ: New York, NY, United States
What they do:
Digital Twins of humans
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HQ: New York, NY, United States
What they do:
Team chat to command all your company's coding agents
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HQ: San Francisco, CA, United States
What they do:
Insurance risk layer for physical AI
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HQ: San Francisco, CA, United States
What they do:
AI for Corporate Security Cameras
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HQ: San Francisco, CA, United States
What they do:
The AI-Native Immigration Law Firm
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HQ: San Francisco, CA, United States
What they do:
Vanta for hardware
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HQ: San Francisco, CA, United States
What they do:
AI automations that implement themselves
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HQ: New York, NY, United States
What they do:
UI building blocks for the agentic internet
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HQ: San Francisco, CA, United States
What they do:
Financial infrastructure for the agent economy
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HQ: San Francisco, CA, United States
What they do:
LLM context compression for better accuracy
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HQ: San Francisco, CA, United States
What they do:
AI production engineer for regulated industries
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HQ: San Francisco, CA, United States
What they do:
Work with agents that already know you
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HQ: San Francisco, CA, United States
What they do:
AI Agents for Government Affairs
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HQ: San Francisco, CA, United States
What they do:
Frontier AI Defenses for Social Engineering Attacks
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HQ: San Francisco, CA, United States
What they do:
Evals, RL environments and training data for creative tasks
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HQ: San Francisco, CA, United States
What they do:
Intelligence for cultural institutions
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HQ: San Francisco, CA, United States
What they do:
Evals for humans
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HQ: San Francisco, CA, United States
What they do:
Your Capable Desktop AI Companion
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HQ: Irvine, CA, United States
What they do:
Autonomous operations for industrial distributors
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HQ: San Francisco, CA, United States
What they do:
Platform + FDEs that rebuild enterprises agent-first
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HQ: San Francisco, CA, United States
What they do:
Helping your company find 10x engineers.
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HQ: San Francisco, CA, United States
What they do:
An open-source operating system for reliable long-running agents
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HQ: Boston, MA, United States
What they do:
Simulations of real people for market research
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HQ: San Francisco, CA, United States