FleetWorks
Hiring
What they do:
AI enabled marketplace matching trucks with jobs
Quick facts:
HQ: San Francisco, CA, United States
Top Deep Tech Startups in San Francisco
This list has 704 startups and was last updated on Oct 15, 2026. 180 of them are hiring right now. Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Aikido Technologies raised $1.72M (Oct 8, 2026).
704 startupsPage 3 of 20
JITX
Hiring
What they do:
Automatic circuit board design.
Quick facts:
HQ: San Francisco, CA, United States
Electric Air
Hiring
What they do:
Tech-enabled heat pump contractor that cuts costs by 60%
Quick facts:
HQ: San Francisco, CA, United States
What they do:
ZBiotics makes genetically engineered probiotics.
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HQ: San Francisco, CA, United States
Topkey
Hiring
What they do:
Topkey is the all-in-one financial operating platform that simplifies expense management for hospitality managers.
Quick facts:
HQ: San Francisco, CA, United States
Deepnight
Hiring
What they do:
Building The Next Generation of Night Vision Devices
Quick facts:
HQ: San Francisco, CA, United States
Oway
Hiring
What they do:
Building the open operating system for the automated physical economy.
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HQ: San Francisco, CA, United States
What they do:
Copia's a for-profit technology company that solves food waste &…
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HQ: San Francisco, CA, United States
General Proximity
Hiring
What they do:
The next generation of induced-proximity medicines.
Quick facts:
HQ: San Francisco, CA, United States
arnata
Hiring
What they do:
AI workers for the logistics industry.
Quick facts:
HQ: San Francisco, CA, United States
Truss
Hiring
What they do:
Truss is a banking and payments network for blue-collar trades.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Water risk mitigation for industrial sites
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HQ: San Francisco, CA, United States
UNISON
Hiring
What they do:
Live between worlds, in UNISON, using the headset we're building!
Quick facts:
HQ: San Francisco, CA, United States
Conduit
Hiring
What they do:
The operating system for shipping and receiving.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
AI Applied Research
Quick facts:
HQ: San Francisco, CA, United States
SalesPatriot
Hiring
What they do:
Supply chain superintelligence for distribution and procurement
Quick facts:
HQ: San Francisco, CA, United States
Reform
Hiring
What they do:
AI Agents for high-stakes work.
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Your voice. Your health. We care.
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HQ: San Francisco, CA, United States
Farcast
Hiring
What they do:
We build advanced satcom user terminals
Quick facts:
HQ: San Francisco, CA, United States
Andromeda Surgical
Hiring
What they do:
Autonomous surgical robots
Quick facts:
HQ: San Francisco, CA, United States
RetailReady
Hiring
What they do:
An AI-powered supply chain compliance engine
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HQ: San Francisco, CA, United States
Cartage
Hiring
What they do:
Autonomous freight coordination
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HQ: San Francisco, CA, United States
Assembly HOA
Hiring
What they do:
AI-native HOA Management Company
Quick facts:
HQ: San Francisco, CA, United States
What they do:
Nuclear-inspired cooling that turns wasted power into more AI compute
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HQ: San Francisco, CA, United States
AirMyne
Hiring
What they do:
Building systems to remove carbon dioxide from air at industrial scale
Quick facts:
HQ: San Francisco, CA, United States
Lanesurf
Hiring
What they do:
Book any load in 10 minutes
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HQ: San Francisco, CA, United States
What they do:
Curtsy is a sustainable clothing resale app.
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HQ: San Francisco, CA, United States
Vorticity
Hiring
What they do:
The Fastest Scientific Computing Platform on the Planet
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HQ: San Francisco, CA, United States
What they do:
Route Optimisation platform for SMB in delivery & home services.
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HQ: San Francisco, CA, United States
What they do:
Using CRISPR to find treatments for cancer and inflammation
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HQ: San Francisco, CA, United States
Fractional
Hiring
What they do:
The place where motivated investors and entrepreneurs co-own together.
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HQ: San Francisco, CA, United States
Posh
Hiring
What they do:
Rapidly deployable energy solutions for modern commercial and…
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HQ: San Francisco, CA, United States
What they do:
Bluedot is a single payment platform for EV drivers and fleets.
Quick facts:
HQ: San Francisco, CA, United States
Diffuse Bio
Hiring
What they do:
Generative AI for protein design
Quick facts:
HQ: San Francisco, CA, United States
Pax
Hiring
What they do:
AI Broker for Tariff Refunds
Quick facts:
HQ: San Francisco, CA, United States
Vendra
Hiring
What they do:
Custom Parts, Manufactured in America 🇺🇸
Quick facts:
HQ: San Francisco, CA, United States