What they do:
Lygos (W16) built and commercialized sustainable, high-performance…
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HQ: San Francisco, CA, United States
Top Deep Tech Startups in San Francisco
This list has 704 startups and was last updated on Oct 15, 2026. 180 of them are hiring right now. Largest teams: DoorDash, GrubMarket, and Instacart. Latest round: Aikido Technologies raised $1.72M (Oct 8, 2026).
704 startupsPage 2 of 20
Agave
Hiring
What they do:
Applied AI for Construction
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HQ: San Francisco, CA, United States
What they do:
Petcube is on the mission to improve lives of pets and pet owners…
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HQ: San Francisco, CA, United States
Reach
Hiring
What they do:
Long range, wireless energy distribution that scales
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HQ: San Francisco, CA, United States
What they do:
Enterprise software to quantify cost-effective decarbonization…
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HQ: San Francisco, CA, United States
What they do:
Building robotic mushroom farms
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HQ: San Francisco, CA, United States
What they do:
We make high definition radar allowing self-driving cars to see in…
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HQ: San Francisco, CA, United States
Overview
Hiring
What they do:
Reshaping industrial quality with AI, hardware, and software
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HQ: San Francisco, CA, United States
What they do:
We make EV charging as simple and reliable as LED lights
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HQ: San Francisco, CA, United States
Living Carbon
Hiring
What they do:
maximizing biomass on low quality land
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HQ: San Francisco, CA, United States
Nash
Hiring
What they do:
Nash is the digital logistics infrastructure for commerce
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HQ: San Francisco, CA, United States
Vooma
Hiring
What they do:
Automation platform for logistics
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HQ: San Francisco, CA, United States
Hub
Hiring
What they do:
Real-world training data for frontier AI labs and robotics.
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HQ: San Francisco, CA, United States
What they do:
Sales software for roofers. Aerial measurements + proposals in seconds
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HQ: San Francisco, CA, United States
What they do:
We grow cells for biotech companies.
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HQ: San Francisco, CA, United States
Flai
Hiring
What they do:
We Bring Customers to Your Dealership
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HQ: San Francisco, CA, United States
What they do:
Order ahead at restaurants and get rewards with friends.
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HQ: San Francisco, CA, United States
Eze
Hiring
What they do:
The easiest way to track, buy, and sell your company’s tech — all in…
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HQ: San Francisco, CA, United States
GETASAP
Hiring
What they do:
AI-Native Fresh Produce Logistics
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HQ: San Francisco, CA, United States
Vori
Hiring
What they do:
Vori is a modern operating system for supermarkets
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HQ: San Francisco, CA, United States
What they do:
Predictive battery management software for electrified fleets
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HQ: San Francisco, CA, United States
Two Dots
Hiring
What they do:
AI fraud prevention and underwriting agent
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HQ: San Francisco, CA, United States
Weave Robotics
Hiring
What they do:
Practical and delightful home robots
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HQ: San Francisco, CA, United States
What they do:
Autonomous drones to help warehouses scan inventory.
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HQ: San Francisco, CA, United States
Seam
Hiring
What they do:
API for IoT Devices
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HQ: San Francisco, CA, United States
Charge Robotics
Hiring
What they do:
Robots that build solar farms
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HQ: San Francisco, CA, United States
Invert
Hiring
What they do:
Data analytics software for biomanufacturing.
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HQ: San Francisco, CA, United States
What they do:
We're building satellites to create a real-time 3D map of the world.
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HQ: San Francisco, CA, United States
Polymath Robotics
Hiring
What they do:
General Autonomy for Industrial Vehicles
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HQ: San Francisco, CA, United States
What they do:
Mass-produced AI strike systems and Counter-UAS
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HQ: San Francisco, CA, United States
What they do:
Targeting Cancer with Click Chemistry
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HQ: San Francisco, CA, United States
SnapMagic
Hiring
What they do:
AI-assisted electronics design
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HQ: San Francisco, CA, United States
ArchForm
Hiring
What they do:
Replacing orthodontic braces with our clear aligner and software
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HQ: San Francisco, CA, United States
Tandem
Hiring
What they do:
AI-native office leasing broker
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HQ: San Francisco, CA, United States
What they do:
Enabling next generation medicines. A comprehensive platform and…
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HQ: San Francisco, CA, United States
Parallel Bio
Hiring
What they do:
Using the immune system to cure disease
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HQ: San Francisco, CA, United States